Research projects : spondyloarthritis (SpA) is a common rheumatic disease that causes considerable disability, due to pain and structural alterations. In particular, there is abnormal ossification in the entheses, leading to ankylosis of this zone where tendon are inserted into bone. We focus on the cellular and molecular mechanisms of bone formation in arthritic enthesis. Better defining the relative contribution of mechanical stress, inflammation, and bone growth factors should help to understand SpA pathophysiology. We investigate in particular the role of some molecular targets that are deregulated in SpA-like conditions, such as the BMP and Wnt pathways and the sphingolipid metabolism.
Main collaborators :
- Experts in lipidomics : Lab. ISA, UMR5280, Team ANABIO-MS (Lyon, France)
- Experts in bone structure : Lab. LYOS, U1033, Team LYSBONE (Lyon, France)
- Experts in rheumatism : Lab. Phy-OS, INSERM UMR1238 (Nantes, France)
Enhanced BMP-2/BMP-4 ratio in patients with peripheral spondyloarthritis and in cytokine- and stretch-stimulated mouse chondrocytes. Briolay A, El Jamal A, Arnolfo P, Le Goff B, Blanchard F, Magne D, Bougault C. Arthritis Res Ther. 2020 Oct 12;22(1):234.
The role of sphingosine 1-phosphate metabolism in bone and joint pathologies and ectopic calcification. -Review- El Jamal A, Bougault C, Mebarek S, Magne D, Cuvillier O, Brizuela L. Bone. 2020 Jan;130:115087.
Cytokine-Induced and Stretch-Induced Sphingosine 1-Phosphate Production by Enthesis Cells Could Favor Abnormal Ossification in Spondyloarthritis. El Jamal A, Briolay A, Mebarek S, Le Goff B, Blanchard F, Magne D, Brizuela L, Bougault C. J Bone Miner Res. 2019 Dec;34(12):2264-2276.
Involvement of sphingosine kinase/sphingosine 1-phosphate metabolic pathway in spondyloarthritis. Bougault C, El Jamal A, Briolay A, Mebarek S, Boutet MA, Garraud T, Le Goff B, Blanchard F, Magne D, Brizuela L. Bone. 2017 Oct;103:150-158.