Research Project: vascular calcification is a pathological but relatively common life-threatening event, associated with atherosclerosis, type 2 diabetes and chronic kidney disease. In these diseases, vascular smooth muscle cells contribute to calcification but the molecular mechanisms involved in calcification remain obscure. Moreover, the impact of calcification, particularly in atherosclerotic plaques, remains controversial. Our projects aim to better understand how arteries calcify, and determine the beneficial and/or harmful impact of different types of vascular calcification. We have an interest in tissue-nonspecific alkaline phosphatase, the only necessary enzyme in bone mineralization.
On the left, progressive aorta calcification in apoe-deficient mice, as longitudinally imaged with 18F-NaF positon emission tomography and computed tomography; on the right the multiple functions of TNAP including its suspected involvement in arterial calcification.
- Experts in TNAP: Jose Luis Millan (San Diego, USA), Caroline Fonta and Lionel Nowak (Toulouse, France)
- Experts in vascular calcification: Claudia Goettsch (Aachen, Germany), Thibaut Quillard (Nantes, France), Emmanuelle Canet-Soulas and Laura Mechtouff (Lyon, France)
- Experts in mineralization: Laurent Beck and Jérome Guicheux (Nantes, France), Marie-Hélène Lafage-Proust and Luc Malaval (Saint-Etienne, France), Slawomir Pikula and Agnieszka Strzelecka-Kiliszek (Warsaw, Poland)