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Research Project: vascular calcification is a pathological but relatively common life-threatening event, associated with atherosclerosis, type 2 diabetes and chronic kidney disease. In these diseases, vascular smooth muscle cells contribute to calcification but the molecular mechanisms involved in calcification remain obscure. Moreover, the impact of calcification, particularly in atherosclerotic plaques, remains controversial. Our projects aim to better understand how arteries calcify, and determine the beneficial and/or harmful impact of different types of vascular calcification. We have an interest in tissue-nonspecific alkaline phosphatase, the only necessary enzyme in bone mineralization.

vascular calcification1vascular calcification2

On the left, progressive aorta calcification in apoe-deficient mice, as longitudinally imaged with 18F-NaF positon emission tomography and computed tomography; on the right the multiple functions of TNAP including its suspected involvement in arterial calcification.

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Grants:

logo era cvdlog fede cadiologo federation de france

logo sfrlogo hypophosphatasi