PUBLICATIONS, ACTES DE CONGRES, BREVETS
Publications
2010
82) L. CARPIO, Z. KLASE, W. COLEY, I. GUENDEL, S. CHOI, R. VAN DUYNE, A. NARAYANAN, K. KEHN-HALL, H. GALONS, N. OUMATA, B. JOSEPH, L. MEIJER et F. KASHANCHI. MicroRNA machinery is an integral component of drug-induced transcription inhibition in HIV-1 infection, J. RNAi Gene Silencing 6, 386 (2010)
81) E. BADARAU, A. PUTEY, F. SUZENET, B. JOSEPH, A. J. BOJARSKI, A.-L. FINARU et G. GUILLAUMET. New insights in the homopiperazine-based 5-HT1A/5-HT7R ligands: synthesis and biological evaluation, J. Enz. Inh. Med. Chem. 25, 301 (2010)
2009
80) G. QUASH et G. FOURNET. Methionine-derived metabolites in apoptosis: therapeutic opportunities for inhibitors of their metabolism in chemoresistant cancer cell, Curr. Med. Chem. 16, 3686 (2009)
79) E. HILTBRAND, G. FOURNET, J. P. GILBERTO, M. J. PARET, J. CHANTEPIE, D. MOREL, J. GORE, U. REICHERT, H. MEHIER, M. E. ROCHEDIX et G. QUASH. Synergetic bitherapyin mice with xenografts oh human prostate cancer using a methional mimic (METLICO) and an aldehyde deshydrogenase 3 inhibitor (MATE): systemic intraperitoneal (IP) and targeted intra-tumoral (IT) administration, Curr. Med. Chem. 16, 1184 (2009)
78) A. PUTEY, F. POPOWYCZ, Q.-T. DO, P. BERNARD, S. K. TALAPATRA, F. KOZIELSKI, C. M. GALMARINI et B. JOSEPH. Indolobenzazepin-7-ones, and 6-, 8- and 9-membered ring derivatives as tubulin polymerization inhibitors: synthesis and structure-activity relationships, J. Med. Chem., 52, 5916 (2009).
77) C. SCHNEIDER, D. GUEYRARD, B. JOSEPH et P. G. GOEKJIAN. Chemoselective functionalization of a-carbolines at the C-2, C-3, C-4 and C-6 positions using Suzuki-Miyaura reactions, Tetrahedron, 65, 5427 (2009).
76) F. POPOWYCZ, C. SCHNEIDER, S. DEBONIS, D. A. SKOUFIAS, F. KOZIELSKI, C. M. GALMARINI et B. JOSEPH. Synthesis and antiproliferative activity of pyrazolo[1,5-a]-1,3,5-triazine myoseverin derivatives, Bioorg. Med. Chem., 17, 3471 (2009).
75) F. POPOWYCZ, G. FOURNET, C. SCHNEIDER, K. BETTAYEB, C. LAMIGEON, P. COLAS, P. BERNARD, L. MEIJER et B. JOSEPH. Pyrazolo[1,5-a]-1,3,5-triazine as a purine bioisostere: access to improved (R)-Roscovitine derivative, J. Med. Chem., 52, 655 (2009).
74) C. SAGNES, G. FOURNET et B. JOSEPH. Unexpected C2-arylation of 1-(pyridin-2-yl)indole-3-carboxaldehyde mediated by copper, Synlett, 433 (2009).
2008
73) K. BETTAYEB, H. SALLAM, Y. FERANDIN, F. POPOWYCZ, G. FOURNET, M. HASSAN, A. ECHALIER, P. BERNARD, J. ENDICOTT, B. JOSEPH et L. MEIJER. N-&-N, a new class of cell death-inducing kinase inhibitors derived from the purine roscovitine, Mol. Cancer Ther., 7, 2713 (2008).
72) C. GALMARINI, F. POPOWYCZ et B. JOSEPH. Cytotoxic nucleoside analogues: different strategies to improve their clinical efficacy, Curr. Med. Chem., 15, 1072 (2008).
71) S. DEBONIS, D. A. SKOUFIAS, R.-L. INDORATO, F. LIGER, B. MARQUET, C. LAGGNER, B. JOSEPH et F. KOZIELSKI. Structure-activity relationship of S-trityl-L-cysteine analogues as inhibitors of the human mitotic kinase Eg5, J. Med. Chem., 51, 1115 (2008).
70) A. ECHALIER, K. BETTAYEB, Y. FERANDIN, O. LOZACH, M. CLEMENT, A. VALETTE, F. LIGER, B. MARQUET, J. A. ENDICOTT, B. JOSEPH et L. MEIJER. Meriolins (3-(pyrimidin-4-yl)-7-azaindoles): synthesis, kinase inhibitory activity, cellular effects and structure of a CDK2/cyclin A/meriolin complex, J. Med. Chem., 51, 737 (2008).
2007
69) S. TANG, M. VERDURAND, B. JOSEPH, L. LEMOINE, A. DAOUST, T. BILLARD, G. FOURNET, D. LE BARS et L. ZIMMER. Synthesis and biological evaluation in rat and cat of [18F]12ST05 as a potential 5-HT6 PET radioligand, Nuc. Med. Biol., 34, 995 (2007).
68) K. BETTAYEB, O. M. TIRADO, S. MARIONNEAU-LAMBOT, Y. FERANDIN, O. LOZACH, J. C. MORRIS, S. MATEO-LOZANO, P. DRUECKES, C. SCHÄCHTELE, M. H. G. KUBBUTAT, F. LIGER, B. MARQUET, B. JOSEPH, A. ECHALIER, J. A. ENDICOTT, V. NOTARIO et L. MEIJER. Meriolins, a new class of cell death-inducing kinase inhibitors with enhanced selectivity for cyclin-dependent kinases, Cancer Res., 67, 8325 (2007).
67) C. SCHNEIDER, D. GUEYRARD, F. POPOWYCZ, B. JOSEPH et P. G. GOEKJIAN. Synthesis of 6-substituted pyrido[2,3-b]indoles by electrophilic substitution, Synlett 2237 (2007).
66) F. POPOWYCZ, J.-Y. MEROUR et B. JOSEPH. Synthesis and reactivity of 4-, 5-, 6-azaindoles, Tetrahedron, 63, 8689 (2007).
65) F. LIGER, F. POPOWYCZ, L. PICOT, T. BESSON, C. M. GALMARINI et B. JOSEPH. Synthesis and antiproliferative evaluation of clausine, mukonine and koenoline bioisosteres, Bioorg. Med. Chem., 15, 5615 (2007).
64) C. NYFFENEGGER, G. FOURNET et B. JOSEPH. Synthesis of 3-amino-5H-pyrrolo[2,3-e]-1,2,4-triazines by Sonogashira/copper(I)-catalyzed heteroannulation, Tetrahedron Lett., 48, 5069 (2007).
63) L. JOUCLA, F. POPOWYCZ, O. LOZACH, L. MEIJER et B. JOSEPH. Access to Paullone analogues by Intramolecular Heck Reaction, Helv. Chim. Acta, 90, 753 (2007).
62) A. PUTEY, F. POPOWYCZ et B. JOSEPH. A non classical route to 2,3-diiodoindole derivatives from indole-2-carboxylic acid, Synlett, 419 (2007).
61) F. POPOWYCZ, P. BERNARD, P. RABOISSON et B. JOSEPH. Synthesis of 8-substituted pyrazolo[1,5-a]-1,3,5-triazine via palladium coupling reactions, Synthesis, 367 (2007).
60) F. POPOWYCZ S. ROUTIER, B. JOSEPH et J.-Y. MEROUR. Synthesis and reactivity of 1H-pyrrolo[2,3-b]pyridine, Tetrahedron, 63, 1031 (2007).
59) A. PUTEY, L. PICOT, L. JOUCLA, T. BESSON et B. JOSEPH. Synthesis of latonduine derivatives via intramolecular Heck coupling reaction, Tetrahedron, 63, 867 (2007).
2006
58) A. PUTEY, G. FOURNET et B. JOSEPH. General and easy access to 11-substituted 4-hydroxy-2,3,4,5-tetrahydro[1,4]diazepino[1,2-a]indol-2-one via palladium coupling reactions, Synlett, 2755 (2006).
2005
57) G. DESFORGES, L. PICOT, C. MONTAGNE, V. THIERY, T. BESSON et B. JOSEPH. Synthesis and preliminary antiproliferative evaluation of 1,3,9-triazacyclopenta[b]fluorene derivatives, J. Enz. Inh. Med. Chem., 20, 569 (2005).
56) L. JOUCLA, C. MONTAGNE, G. FOURNET et B. JOSEPH. Synthesis of azepinoindole derivatives via oxidative palladium couplings, Lett. Org. Chem., 2, 707 (2005).
55) C. MONTAGNE, N. LAURENT, J.-Y. MEROUR et B. JOSEPH. Synthesis and reactivity of azepino[3,4-b]indoles, J. Heterocyclic Chem., 42, 1433 (2005).
54) L. JOUCLA, A. PUTEY et B. JOSEPH. Synthesis of fused heterocycles with a benzazepinone moiety via intramolecular Heck coupling, Tetrahedron Lett., 46, 8177 (2005).
53) S. CELANIRE, C. DESCAMPS-FRANCOIS, B. LESUR, G. GUILLAUMET et B. JOSEPH. Synthesis of 14-membered jaspamide derivatives, Lett. Org. Chem., 2, 528 (2005).
52) C. MONTAGNE, G. FOURNET et B. JOSEPH. Synthesis of homocarbonyltopsentine analogues, Synthesis, 136 (2005).
2004
51) J. PERRON, B. JOSEPH et J.-Y. MEROUR. Synthesis of substituted azepino[3,4-b]indole-1,5-dione, Eur. J. Org. Chem., 4606 (2004).
50) J. PERRON, B. JOSEPH et J.-Y. MEROUR. Access of azepino[3,4-b]indole-1,5-dione derivatives by ring-closing metathesis, Tetrahedron, 60, 10099 (2004).
49) G. DESFORGES, C. BOSSERT, C. MONTAGNE et B. JOSEPH. Synthesis of imidazolo[5,4-b]carbazole-4,10-quinones, Synlett, 1306 (2004).
2003
48) C. PAIN, S. CELANIRE, G. GUILLAUMET et B. JOSEPH. Synthesis of 5-substituted 2-(4- or 3-methoxyphenyl)-4(1H)-quinolones, Tetrahedron, 59, 9627 (2003).
47) C. PAIN, S. CELANIRE, G. GUILLAUMET et B. JOSEPH. Synthesis of quinolone-fused multiring-sized heterocycles via combined claisen rearrangement/ring-closing metathesis reactions, Synlett, 2089 (2003).
46) B. JOSEPH, A. BEHARD, B. LESUR et G. GUILLAUMET Convenient synthetic routes to 5-substituted 3-(4-methoxyphenyl)-4(1H)-quinolones, Synlett, 1542 (2003).
45) C. MONTAGNE, G. FOURNET et B. JOSEPH. An efficient synthetic route to homocarbonyltopsentine, Synlett, 1533 (2003).
44) J. PERRON, B. JOSEPH et J.-Y. MEROUR. First synthesis of pyrrolo[1,2:1',2']azepino[5,6-b]indole derivatives, Tetrahedron Lett., 44, 6553 (2003).
43) Y. DAVION, B. JOSEPH, V. BENETEAU, J.-M. LEGER, C. JARRY et J.-Y. MEROUR. A synthesis of pyrano[3,2-b]indole derivatives based on intramolecular hetero Diels-Alder of 2-benzyliden-1H-indol-3(2H)-ones, Helv. Chim. Acta, 86, 2687 (2003).
42) J. PERRON, B. JOSEPH et J.-Y. MEROUR. Synthesis and reactivity of azepino[3,4-b]indole-1,5-diones, Tetrahedron, 59, 6650 (2003).
41) L. ZIMMER, G. FOURNET, B. JOSEPH, G. GUILLAUMET et D. LE BARS. Carbon-11 labelling of 8{{3-[4-(2-[11C]methoxyphenyl)piperazin-1-yl]-2-hydroxypropyl}oxy}thiochromane, a presynaptic 5-HT1A receptors agonist, and its in vivo evaluation in anaesthetised rat and in awake cat, Nucl. Med. Biol., 30, 541 (2003).
2002
40) L. CHACUN-LEFEVRE, V. BENETEAU, B. JOSEPH et J.-Y. MEROUR. Ring closure metathesis of indole 2-carboxylic acid allylamide derivatives, Tetrahedron, 58, 10181 (2002).
39) S. MAYER, B. JOSEPH, J.-Y. MEROUR et G. GUILLAUMET. A synthetic route to hexahydro[1,4]oxazino[2,3-H or 3,2-J]carbolines, Synthesis, 1871 (2002).
38) S. MAYER, J.-Y. MEROUR, B. JOSEPH et G. GUILLAUMET. Synthesis and reactivity of 1,4-oxazinoindole derivatives, Eur. J. Org. Chem., 1646 (2002).
37) B. JOSEPH, F. DARRO, A. BEHARD, B. LESUR, F. COLLIGNON, C. DECAESTECKER, A. FRYDMAN, G. GUILLAUMET et R. KISS. 3-Aryl-2-quinolones derivatives: synthesis and characterization of in vitro and in vivo antitumor effects with emphasis on a new therapeutical target connected with cell migration, J. Med. Chem., 45, 2543 (2002).
2001
36) R. REZAIE, B. JOSEPH, J. B. BREMNER, P. DELAGRANGE, C. KOPP, R. MISSLIN, B. PFEIFFER, P. RENARD et G. GUILLAUMET. 5-Substituted 3,4-dihydro-3-amino-2H-1-benzopyran derivatives: synthesis and interaction with serotoninergic receptors, J. Pharm. Pharmacol., 53, 959 (2001).
35) L. CHACUN-LEFEVRE, B. JOSEPH et J.-Y. MEROUR. Intramolecular Heck cyclisation of alkenyl 3-iodoindole-2-carboxamide derivatives, Synlett, 848 (2001).
34) B. JOSEPH, M. FACOMPRE, H. DA COSTA, S. ROUTIER, J.-Y. MEROUR, P. COLSON, C. HOUSSIER et C. BAILLY. Synthesis, cytotoxicity, DNA interaction and topoisomerase II inhibition of tetrahydropyrrolo[3,4-a]carbazole-1,3-dione and tetrahydropyrido[3,2-b]pyrrolo[3,4-g]indole-1,3-dione derivatives, Bioorg. Med. Chem., 9, 1533 (2001).
33) J.-Y. MEROUR et B. JOSEPH. Synthesis and reactivity of 7-azaindoles (1H-pyrrolo[2,3-b]pyridine), Curr. Org. Chem., 5, 471 (2001).
2000
32) B. JOSEPH, D. ALAGILLE, J.-Y. MEROUR et S. LEONCE. Synthesis and in vitro cytotoxic evaluation of N-substituted benzo[5,6]cyclohepta[b]indoles, Chem. Pharm. Bull., 48, 1872 (2000).
31) B. JOSEPH, S. ROUTIER, J.-Y. MEROUR, P. COLSON, C. HOUSSIER et C. BAILLY. DNA but not topoisomerase is a target for a cytotoxic benzo[5,6]cyclohepta[b]indol-6-one derivative, Anticancer Research, 20, 3307 (2000).
30) L. CHACUN-LEFEVRE, B. JOSEPH et J.-Y. MEROUR. Synthesis and reactivity of azepino[3,4-b]indol-5-yl trifluoromethane sulfonate, Tetrahedron, 56, 4491 (2000).
29) B. JOSEPH, H. DA COSTA, J.-Y. MEROUR et S. LEONCE. Synthesis of pyrido[2,3-b]indole derivatives via Diels-Alder reactions of 2- and 3-vinylpyrrolo[2,3-b]pyridines, Tetrahedron, 56, 3189 (2000).
28) A. MOUADDIB, B. JOSEPH, A. HASNAOUI et J.-Y. MEROUR. Synthesis of indolo[3,2-c]quinoline and pyrido[3',2':4,5][3,2-c]quinoline derivatives, Synthesis, 549 (2000).
1999-1990
27) A. MOUADDIB, B. JOSEPH, A. HASNAOUI et J.-Y. MEROUR. Synthesis of 6-substituted 5,6,7,12-tetrahydrobenzo[4,5]cyclohepta[b]indol-12-one derivatives, Heterocycles, 51, 2127 (1999).
26) A. MOUADDIB, B. JOSEPH, A. HASNAOUI et J.-Y. MEROUR. Synthesis of benzo[5',6']cyclohepta[4,5]pyrrolo[2,3-b]pyridin-12-one, Tetrahedron Lett., 40, 5853 (1999).
25) B. JOSEPH, D. ALAGILLE, C. ROUSSEAU et J.-Y. MEROUR. Synthesis of benzo[5,6]cyclohepta[b]indol-6-one derivatives, Tetrahedron, 55, 4341 (1999).
24) R. REZAIE, B. JOSEPH, J. B. BREMNER et G. GUILLAUMET. Synthesis of 5-substituted 3,4-dihydro-3-amino-2H-1-benzopyran derivatives, Heterocycles, 48, 2079 (1998).
23) Y. DAVION, B. JOSEPH et J.-Y. MEROUR. Intramolecular hetero Diels-Alder with inverse electron demand: Synthesis of pyrano[3,2-b]indole derivatives, Synlett, 1051 (1998).
22) B. JOSEPH, V. CHAPELLIER, J.-Y. MEROUR et S. LEONCE. Synthesis and antitumoral evaluation of 12-substituted-6,7-dihydrobenzo[4,5]cyclohept[1,2-b]indole derivatives, Heterocycles, 48, 1423 (1998).
21) B. JOSEPH, O. CORNEC et J.-Y. MEROUR. Intramolecular Heck reaction: synthesis of benzo[4,5]cyclohepta[b]indole derivatives, Tetrahedron, 54, 7765 (1998).
20) J.-Y. MEROUR, S. PIROELLE et B. JOSEPH. Synthesis and reactivity of 1H-indol-3(2H)-one and related compounds, Trends in Heterocycl. Chem., 5, 115 (1997).
19) B. JOSEPH, O. CORNEC, J.-Y. MEROUR, X. SOLANS et M. FONT-BARDIA. Synthesis of 6,7-dihydrobenzo[4,5]cyclohept[1,2-b]indol-12(5H)-one and related compounds, J. Heterocyclic Chem., 37, 525 (1997).
18) B. JOSEPH, B. MALAPEL et J.-Y. MEROUR. Indol-2-yl triflate: a versatile reagent for the synthesis of 2-substituted indoles, Synth. Commun., 26, 3289 (1996).
17) O. CORNEC, B. JOSEPH et J.-Y. MEROUR. Intramolecular Heck reaction: synthesis of potential antiinflammatory agents, Tetrahedron Lett., 36, 8587 (1995).
16) B. JOSEPH, A. BENARAB et G. GUILLAUMET. Synthesis of N-substituted 3-aminomethyl-2,3-dihydrofuro[2,3-c]pyridines, potent serotoninergic ligands, Heterocycles, 41, 2769 (1995).
15) C. GARDRAT, B. JOSEPH, P. ROLLIN, C. VITRY et G. BOURGEOIS. Analyse de spectres LSIMS de glycobrassicines, Analusis, 23, 222 (1995).
14) B. JOSEPH et P. ROLLIN. Synthesis of O-protected thiohydroximate-linked pseudodisaccharides, Carbohydr. Res., 266, 321 (1995).
13) B. JOSEPH, A. BENARAB et G. GUILLAUMET. 8-Piperazinyl-2,3-dihydro-1,4-dioxino[2,3-b]pyridine derivatives: synthesis and interaction with 5-HT serotonin binding sites, Heterocycles, 38, 1355 (1994).
12) J. P. PRALY, R. FAURE, B. JOSEPH, L. KISS et P. ROLLIN. Synthesis, structure and enzymatic evaluation of new spirooxathiazole sugar derivatives, Tetrahedron, 50, 6559 (1994).
11) L. BROCHARD, B. JOSEPH, M.C. VIAUD et P. ROLLIN. (Z)-Stereospecific addition of glycosylmercaptans on nitrilium betaines. Synthesis of 1-S-glucopyranosyl arylthiohydroximates, Synth. Commun., 24, 1403 (1994).
10) B. JOSEPH et P. ROLLIN. A new class of heteroarylthioglycosides. De Novo synthesis of pyrazol-3-ylthioglycopyranosides, J. Chem. Res. (S), 128 (1994) et J. Chem. Res. (M), 770 (1994).
9) B. JOSEPH et P. ROLLIN. Synthesis of aza-analogs of natural and artificial desulfoglucosinolates, J. Carbohydr. Chem., 12, 1127 (1993).
8) S. CHEVOLLEAU, B. JOSEPH, P. ROLLIN et J. TULLIEZ. Synthesis of 3H-labelled glucobrassicin, a potential radiotracer for metabolic studies of indole glucosinolates, J. Labelled Compd. Radiopharm., 33, 671 (1993).
7) B. JOSEPH et P. ROLLIN. Synthesis of 1,5-dithio-D-glucopyranose and some of its biologically relevant derivatives, J. Carbohydr. Chem., 12, 719 (1993).
6) J.P. PRALY, S. BOYE, B. JOSEPH et P. ROLLIN. Novel cyclization of D-glucopyranosyl-(Z)-thiohydroximates leading to new anomeric spirooxathiazole derivatives, Tetrahedron Lett., 34, 3419 (1993).
5) C. GARDRAT, A. QUINSAC, B. JOSEPH et P. ROLLIN. Synthesis of indole glycosinolates, sugar-variants of naturally-occurring glucobrassicin, Heterocycles, 35, 1015 (1993).
4) B. JOSEPH et P. ROLLIN. Sugar thiochemistry. First synthesis of 1,5-dithio-D-glucopyranose and related thia-analogs of glucosinolates, Phosphorus, Sulfur and Silicon, 74, 467 (1993).
3) M. LAFOSSE, P. MARINIER, B. JOSEPH et M. DREUX. A study of amphiphilic behavior of alkylglycoside surfactants using reversed phase liquid chromatography, J. Chromatogr., 623, 277 (1992).
2) T. BESSON, B. JOSEPH, P. MOREAU, M.C. VIAUD, G. COUDERT et G. GUILLAUMET. Synthesis and fluorescent properties of new heterobifunctional fluorescent probes, Heterocycles, 34, 273 (1992).
1) M. BLANC-MUESSER, H. DRIGUEZ, B. JOSEPH, M.C. VIAUD et P. ROLLIN. First synthesis of alpha-glucosinolates, Tetrahedron Lett., 31, 3867 (1990).
Actes de congrés
1) M. JARRY, M. T. SCHOUFT, F. LIGER, B. MARQUET, B. JOSEPH, T. LEFEBVRE, M. C. THONON, L. MEIJER, H. CASTEL et P. GANDOLFO. Effects of a series of meriolins, new class of cyclin-dependent kinase inhibitors, on glioma proliferation Glia, 57, S168 (2009).
Brevets
7) C. GAMBACORTI-PASSERINI, L. MOLIGNY, L. SCAPOZZA, S. AHMED, P. G. GOEKJIAN, D. GUEYRARD, F. POPOWYCZ, B. JOSEPH et C. SCHNEIDER. Alpha-carboline inhibitors of NMP-Alk, Ret and Bcr-Abl. Application: EP 2008-15802 (08/09/2008), Demande EP 2161271 (10/03/2010), PCT int. Appl. WO 2010/025872 (11/03/2010).
6) L. MEIJER, B. JOSEPH, F. LIGER et B. MARQUET. Composés pyrrolo[2,3-b]pyridine, composés azaindoles utiles dans la synthèse de ces composés pyrrolo[2,3-b]pyridine, leurs procédés de fabrication et leurs utilisations. Application: FR 07-01138 (16/02/07). Demande FR 2912744 (22/08/08), PCT int. Appl. WO 2008/129152 (30/10/2008).
5) B. JOSEPH, L. MEIJER et F. LIGER. Nouveaux dérivés de 9H-pyrido[2,3-b]indole, leur procédé de préparation, ainsi que les compositions pharmaceutiques contenant de tels composés. Application: FR 04-10683 (11/10/2004). Demande FR 2876377 (14/04/2006), PCT int. Appl. WO 2006/040451 (20/04/2006).
4) P. BERNARD, P. RABOISSON et B. JOSEPH. Novel substituted pyrazolo[1,5-a]-1,3,5-triazine derivatives and their analogues, pharmaceutical compositions containing same, use thereof as medecine and methods for preparing same. PCT int. Appl. WO 2004/011464 (5/02/2004).
3) F. DARRO, B. JOSEPH, R. KISS, A. FRYDMAN et G. GUILLAUMET. Use of 2- and 4-quinolones for inhibiting intimal neo-proliferation. Application: FR 00-11738 (14/09/00), Demande FR 2813791 (15/03/2002), PCT int. Appl. WO 2002/22074 A2 (21/03/2002).
2) B. JOSEPH, F. DARRO, G. GUILLAUMET, R. KISS et A. FRYDMAN. Compositions pharmaceutiques comprenant des 4-quinolones. Application: FR 1999-10492 (13/08/99), Demande FR 2797444 (16/02/2001), PCT int. Appl. WO 2001/12607 A2 (22/02/2001).
1) B.
JOSEPH, F. DARRO, G. GUILLAUMET, R. KISS et A. FRYDMAN.
Pharmaceutical compositions comprising 2-quinolones with
activity against the proliferation of clonogenic cells in
tumors. Application: FR 1998-9060 (15/07/98), Demande FR
2781218 (21/01/2000), PCT int. Appl. WO 2000/03990
(27/01/2000).
