forme_membres_ICBMS Prof Thierry LOMBERGET

Prof Thierry LOMBERGET

Full professor

thierry.lomberget@univ-lyon1.fr

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About Thierry

Thierry obtained his university degrees at University Claude Bernard of LYON where, after a master degree in Fine Organic Chemistry, he obtained a PhD in Organic Chemistry in 2002. Under the joint supervision of Drs Geneviève Balme and Didier Boussi, he developed synthetic methodologies using palladium-catalysed key steps, combined with pericyclic reactions (Diels & Alder and electrocyclisations of conjugated trienes). Then, he joined the group of Pr Peter Kündig in Geneva as a post-doctoral researcher, working on dessymetrisation reactions of naphtalene Cr(CO)3 complexes.

He went back to France and became a member of the faculty of Pharmacy of Lyon (ISPB) as a teacher-researcher in 2004 (ATER then assistant professor). He obtained his research habilitation in 2010 and was promoted as a full Professor of Medicinal Chemistry in 2016.

Thierry is also the leader of COSSBA team (COnception & Synthesis of Biologically active Substances) of the ICBMS, created in 2021.

Research interests

Trained in synthesis methodology, organometallic chemistry and asymetric synthesis, Thierry has developped skills and research themes in medicinal and bioorganic chemistry, since joining the faculty of Pharmacy. Different approaches combining pharmacomodulation and biophysical techniques (such as NMR, Mass Spectrometry…) allowed him to develop molecules of therapeutic interest in cancerology (kinases inhibitors, Tubulin Polymerisation Inhibitors, anti-chemoreversal agents targeting Multi Drug Resistance phenotype), and in infectiology, targeting bacterial or viral proteins. In parallel to methodologies for the synthesis of heterocycles, numerous collaborations with biochemists and structural biologists allowed him to develop research projects at the interface of biology and medicine.

Selected publications

- Pharmacomodulation of a ligand targeting the HBV capsid hydrophobic pocket.

Briday, M.; Hallé, F.; Lecoq, L.; Radix, S.; Martin, J.; Montserret, R.; Dujardin, M.; Fogeron, M-L.; Nassal, M.; Meier, B. H.; Lomberget T.; Böckmann, A. Chem. Sci. 2022, 13, 8840–8847.

 

- Combretastatin A-4 sulfur-containing heterocyclic derivatives: synthesis, antiproliferative activities and molecular docking studies.

Faouzi, A.; Arnaud, A.; Bancet, A.; Barette, C.; Preto, J.; Do, C. V.; Jordheim, L. P.; Bousfiha, Z.; Nguyen, T. T. B.; Verrière, M.; Farce, A.; Fauvarque, M.-O.; Barret, R.; Lomberget, T. Eur. J. Med. Chem. 2021, 215, 113275.

 

- 2-Aminothiazole derivatives as selective allosteric modulators of the protein kinase CK2. Part 1: Identification of an allosteric binding site.

Bestgen, B.; Krimm, I.; Kufareva, I.; Kamal, A. A. M.; Seetoh, W.-G.; Abell, C.; Hartmann, R. W.; Abagyan, R.; Cochet, C.; Le Borgne, M.; Engel, M.; Lomberget, T. J. Med. Chem. 2019, 62, 1803–1816.

 

- Synthesis of New Steroidal Inhibitors of P-glycoprotein-mediated Multidrug Resistance and Biological Evaluation on K562/R7 Erythroleukemia Cells.

Rolland de Ravel, M.; Alameh, G.; Melikian, M.; Mahiout, Z.; Emptoz-Bonneton, A.; Matera, E.-L.; Lomberget, T.; Barret, R.; Rocheblave, L.; Walchshofer, N.; Beltran, S.; El Jawad, L.; Mappus, E.; Grenot, C.; Pugeat, M.; Dumontet,C.; Le Borgne, M.; Cuilleron, C. Y. J. Med. Chem. 2015, 58, 1832–1845.

Publications Find the most recent scientific contributions

Cancer selective cell death induction by a bivalent CK2 inhibitor targeting the ATP site and the allosteric αD pocket

Alexandre Bancet, Rita Frem, Florian Jeanneret, Angélique Mularoni, Pauline Bazelle, Caroline Roelants, Jean-Guy Delcros, Jean-François Guichou, Catherine Pillet, Isabelle Coste, Toufic Renno, Christophe Battail, Claude Cochet, Thierry Lomberget, Odile Filhol, Isabelle Krimm

iScience 2024, 27, 108903

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Pharmacomodulation of a ligand targeting the HBV capsid hydrophobic pocket

Mathilde Briday, François Hallé, Lauriane Lecoq*, Sylvie Radix, Juliette Martin, Roland Montserret, Marie Dujardin, Marie-Laure Fogeron, Michael Nassal, Beat H. Meier, Thierry Lomberget*, Anja Böckmann*

Chem. Sci. 2022, 13, 8840-8847

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A journey through Hemetsberger-Knittel, Leimgruber-Batcho and Bartoli reactions: access to several hydroxy 5- and 6-azaindoles

Sylvie Radix, François Hallé, Zahia Mahiout, Amélie Teissonnière, Grégoire Bouchez, Ludovic Auberger, Roland Barret, Thierry Lomberget*

Helv. Chim. Acta 2022, 105, e202100211.

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Combretastatin A-4 sulfur-containing heterocyclic derivatives: synthesis, antiproliferative activities and molecular docking studies

Abdelfattah Faouzi, Alexandre Arnaud, Alexandre Bancet, Caroline Barette, Jordane Preto, Cong Viet Do, Lars Petter Jordheim, Zineb Bousfiha, Thi Thanh Binh Nguyen, Marion Verrière, Amaury Farce, Marie-Odile Fauvarque, Roland Barret, Thierry Lomberget*

Eur. J. Med. Chem. 2021, 215, 113275

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