M Laurent SOULERE

Bio

During his PhD (1999-2001), Dr Laurent Soulère worked under the supervision of Prof Jacques Périé and Dr Pascal Hoffmann at the University of Paul Sabatier (Toulouse, France). He was then post-doc fellow in the Prof Herbert Waldmann’s group in Dortmund, Germany (2002-2003). In September 2003, he work at the University of Perpignan at the laboratory of Chemistry of biomolecules and Environment. In 2004, he joined as Maître de conferences (INSA LYON) the Institute for Molecular and Supramolecular Chemistry and Biochemistry (ICBMS, Lyon, France) in the Organic and Bioorganic Chemistry team.

Research interests

His research interest is focused on the chemistry of bioactives molecules targeting bacterial quorum sensing and the FtsZ protein; the chemistry of biomolecules, in particular lipids and phospholipids and also molecular modelling study.

Selected publications

Thibaut Barbier, Alexia Barbry, Jérémy Magand, Cédric Badiou, Floriane Davy, Anne Baudouin, Yves Queneau, Oana Dumitrescu, Gérard Lina and Laurent Soulère “Synthesis and Biological Evaluation of Benzo[b]thiophene Acylhydrazones as Antimicrobial Agents against Multidrug-Resistant Staphylococcus aureus”  Biomolecules  (2022), 12, 131.

Laurent Soulère “Computer-Assisted Conformational Analysis of Small Molecules Using VEGA ZZ, a Freely Available Software Program, as an Introduction to Molecular Modeling” J. Chem. Educ. (2021) 98, 8, 2709–2713

Qiang Zhang, Erwann Jeanneau, Yves Queneau, Laurent Soulère “(2R)- and (2S)-2-hydroxy- hexanoyl and octanoyl-L-homoserine lactones: New highly potent Quorum Sensing modulators with opposite activities” Bioorganic Chemistry, (2020), 104, 104307.

Stevens Ann, Queneau Yves, Soulere Laurent, von Bodman Susanne, Doutheau Alain “Mechanisms and Synthetic Modulators of AHL-Dependent Gene Regulation” Chemical Reviews (2011), 111, 4-27.