Bio
Nicolas Duguet graduated from Institut National des Sciences Appliquées (INSA) of Rouen in 2003 and received his Ph.D. in 2006 from the University of Rouen, under the supervision of Dr. Jacques Maddaluno working on chiral lithium amides. During his Ph.D. studies, he spent some time working in collaboration with Pr. Kiyoshi Tomioka in Kyoto University, Japan. In 2007, he joined the group of Dr. Andrew D. Smith at the University of St Andrews, Scotland, UK as a postdoctoral fellow (Leverhulme Trust) where he stayed for two years developing novel organocatalytic methodologies using N-heterocyclic carbenes. He moved back to France in 2009 for second postdoc in medicinal chemistry at the University of Orléans under the guidance of Pr. Sylvain Routier. In 2010, he was appointed assistant professor at the University Claude Bernard Lyon 1 and was affiliated to the Institut de Chimie et Biochimie Moléculaires & Supramoléculaires (ICBMS) in the group of Pr Marc Lemaire. He is now associate professor (habilitation in 2016) in the team Catalysis, Synthesis & Environment (CASYEN), working in the field of green chemistry and sustainable development.
Research interests
His current work aims at the development of original catalytic methods mainly based on (supported) organocatalysis but also on organometallic species (homogeneous and heterogeneous). He is particularly interested in developing new methodologies with high atom economy with a particular attention to the use of non-toxic solvents or solvent-free conditions. New reactivities are explored to allow the transformation of molecules from biomass (polyols and sugars, vegetable oils, fatty acids, glycerol, etc.) and CO2. These methods are applied to the preparation of “building-blocks” with higher added value or products of interest such as surfactants, solvents, antimicrobials and monomers.
Selected publications
Organocatalytic cleavage of fatty 1,2-diketones to esters. N. D. Vu, R. Chavallard, T. De Dios Miguel, N. Duguet, M. Lemaire, ACS Sustainable Chem. Eng. 2019, 7, 13865−13872. link
Biobased aldehydes from fatty epoxides through thermal cleavage of b-hydroxy hydroperoxides. T. De Dios Miguel, N. D. Vu, M. Lemaire, N. Duguet, ChemSusChem 2021, 14, 379–386. link
Thermomorphic polyethylene-supported organocatalysts for the valorization of vegetable oils and CO2. A. Akhdar, K. Onida, N. D. Vu, K. Grollier, S. Norsic, C. Boisson, F. D’Agosto, N. Duguet, Adv. Sustainable Syst. 2021, 5, 2000218. link
Selective Catalytic Oxidation of diglycerol. H. Wang, N. D. Vu, G.-R. Chen, E. Métay, N. Duguet, M. Lemaire, Green Chem. 2021, 23, 1154–1159. link
Organocatalytic synthesis of substituted vinylene carbonates. K. Onida, A. Haddleton, S. Norsic, C. Boisson, F. D’Agosto, N. Duguet, Adv. Synth. Catal. 2021, 363, 5129– 5137. link
Publications Find the most recent scientific contributions
Eco-Friendly Synthesis of Cardanol-Based AB Monomer for Formaldehyde-Free Phenolic Thermosets
Benoît Briou,* Lucas Jégo, Thomas De Dios Miguel, Nicolas Duguet,* Sylvain Caillol
RSC Sustain. 2023, 1, 994-1005.
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Chemical Upcycling of Poly(bisphenol A carbonate) to Vinylene Carbonates through Organocatalysis
Killian Onida, Mohamad Fayad, Sébastien Norsic, Olivier Boyron, Nicolas Duguet*
Green Chem. 2023, 25, 4282-4291
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Direct Synthesis of Vinylene Carbonates from Aromatic Aldehydes
Killian Onida, Leyli Ibrahimli, Nicolas Duguet*
Eur. J. Org. Chem. 2022, e202200153
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Cleavage of aliphatic α-Hydroxy Ketones by Evolved Transketolase from Geobacillus stearothermophilus
Hubert Casajus, Aurélie Lagarde, Lionel Nauton, Nazim Ocal, Martin Leremboure, Wolf-Dieter Fessner, Nicolas Duguet, Franck Charmantray,* Laurence Hecquet*
ACS Catal. 2022, 12, 3566-3576
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Organocatalytic synthesis of substituted vinylene carbonates
Killian Onida, Alice Haddleton, Sébastien Norsic, Christophe Boisson, Franck D’Agosto, Nicolas Duguet*