Chemistry at the interface with Biology and MedicineSysChem: Complex prebiotic and biomolecular systems

SysChem stands for "systems chemistry of biomolecules and prebiotic chemistry". We are generally studying the systemic interactions between synthetic lipophilic peptides, synthetic nucleic acids and racemic, scalemic or natural phospholipids to approach the self-evolution of synthetic living cells. The growth and division of giant phospholipid vesicles is one major research topic. We are studying the mechanism and scope of the phosphorylation of alkanols, nucleosides and glycerols under prebiotic conditions. We also engage in developing synthetic vaccines based on glycolipid vesicles.

More about the SysChem group members and recent publications at: https://www.icbms.fr/en/team/20-lco2-html

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Publications Find the most recent scientific contributions

How can we solve the problem of bioprintability to overcome the bioprinting challenges?

Alizée Mosnier, Imen Halima & Edwin-Joffrey Courtial

MRS Bulletin (2024)

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Unlocking the potential of bio-inspired bioinks: A collective breakthrough in mammalian tissue bioprinting

Marquette, C. A.; Chastagnier, L.; Da Sousa, B.; Chocarro-Wrona, C.; Courtial, E.-J.; Rae, E.; Thomann, C.; Carre, A.; Essayan, L.; Pasuch, A. J.; Mosnier, A.; Devillard, C.; Petiot, E.; Lemarié, L.; Matera, E.-L.; Simoes, M.; Dumontet, C.; Cuella Martin, C.; Pechtimaldjian, L.; Pécheur, E.-I.; Maguer-Satta, V.; Michelet, M.; Plissonnier, M.-L.; Archer, F.; Moreau, K.; Dufaud, M.; Zaupa, C.; Balloul, J.-M.; Pruvost, Q.; Dauphin, T.; Mosser, M.; Pragnère, S.,

Bioprinting, 2024, 41: e00351

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Space radiation damage rescued by inhibition of key spaceflight associated miRNAs

J. Tyson McDonald, Jang Keun Kim,Lily Farmerie,Meghan L. Johnson, Nidia S. Trovao, Shehbeel Arif, Keith Siew, Sergey Tsoy, Yaron Bram, Jiwoon Park,EliahOverbey,Krista Ryon, Jeffrey Haltom, Urminder Singh, Francisco J. Enguita, Victoria Zaksas, Joseph W. Guarnieri, Michael Topper, Douglas C. Wallace, Cem Meydan, Stephen Baylin, Robert Meller, Masafumi Muratani, D.Marshall Porterfield, Brett Kaufman, Marcelo A. Mori, Stephen B. Walsh, Dominique Sigaudo-Roussel, Saida Mebarek, Massimo Bottini, Christophe A. Marquette, Eve Syrkin Wurtele, Robert E. Schwartz, DiegoGaleano, Christopher E. Mason, Peter Grabham & Afshin Beheshti

Nat. Commun. 2024, 15: 4825

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Convergent synthesis of N-(4-(3-ethoxy-2-hydroxypropyl)phenyl)-2-(methylthio) acetamide precursor of the suplatast tosylate

Margherita Colombo, Yousef Joqmara, Guillaume Pilet, Michele Fiore

Trends in Organic Chemistry, 2024, 24, 79-92

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Biochemical, Bioinformatic, and Structural Comparisons of Transketolases and Position of Human Transketolase in the Enzyme Evolution

Biochemistry, 2024

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