Chemistry at the interface with Biology and MedicineChimie médicinale
Several teams are developing Medicinal Chemistry projects, i.e. the design and optimization of molecular structures (small molecules or more elaborated scaffolds), with therapeutic and chemobiological applications. Several strategies could be developped and use advantage of key informations from structure-activity relationship studies, screening campaigns, the diversity of products of natural origin, and measurements of ligand/protein interactions using different techniques, such as X-ray diffraction, Nuclear Magnetic Resonance, Surface Plasmon Resonance, Isothermal Calorimetric Titration or Mass Spectrometry.
Publications Find the most recent scientific contributions
Paper-based electrodes as a tool for detecting ligninolytic enzymatic activities
Fall, I., Doumèche, B., Abdellaoui, S., Rémond C., Rakotoarivonina, H., Ochs M.
Bioelectrochem. 2023, 156, 108609
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Synthetic outer membrane vesicles bearing Tn antigen
Carolina Chieffo, Arnaud Comte, Peter Strazewski and Michele Fiore*
European Journal of Organic Chemistry 2023
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Difluoromethoxylated Ketones as Building Blocks for the Synthesis of Challenging OCF2H-Bearing N-Heterocycles
A. Loison, G. Hanquet, F. Toulgoat, T. Billard, A. Panossian and F. R. Leroux
Eur. J. Org. Chem. 2023, 26, e202300695
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The origin and early evolution of life: homochirality emergence in prebiotic environments
Carolina Chieffo, Anastasiia Shvetsova, Fryni Skorda, Augustin Lopez, and Michele Fiore*
Astrobiology 2023, 23
Read the whole publicationIdentifying Potent Nonsense-Mediated mRNA Decay Inhibitors with a Novel Screening System
Julie Carrard , Fiona Ratajczak , Joséphine Elsens , Catherine Leroy , Rebekah Kong , Lucie Geoffroy , Arnaud Comte , Guy Fournet , Benoît Joseph , Xiubin Li , Sylvie Moebs-Sanchez, Fabrice Lejeune