Chemistry at the interface with Biology and MedicineChimiothérapies tropicales

Our research is based on our medical and pharmaceutical background and a bed-to-bench strategy. The team has strong experience in malaria research, from basic sciences to applied diagnosis and treatment, including prospective clinical trials. The group is fully equipped to study clones of malaria parasites and isolates from patients leading to direct proof of concept of our research hypothesis. Among these, the effect of innovative single dose drugs on malaria transmission and disease severity is explored in the lab and during long-term prospective clinical trials in endemic west-African and Asian countries. We are also involved in antifungal stewardship aiming at an optimal use of antifungals through careful selection of agents based on patient profile, target organism, toxicity, cost, as well as the likelihood of emergence and spread of antifungal resistance. In that perspective, we are implementing stewardship programs in health care facilities to limit overuse or misuse of antifungals proven to be responsible for an increase in resistance.

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Publications Find the most recent scientific contributions

Machine learning approaches for the identification of ligands of the autophagy marker LC3

Laurent Soulère, Yves Queneau

Artificial Intelligence Chemistry 1(2) (2023) 100022

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Importance of the 2,6-Difluorobenzamide Motif for FtsZ Allosteric Inhibition: Insights from Conformational Analysis, Molecular Docking and Structural Modifications

T. Barbier, O. Dumitrescu, G. Lina, Y. Queneau, L. Soulère

Molecules, 2023, 28(5), 2055

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Access to Saturated Aza-Heterocycles using the Borrowing Hydrogen Methodology

Maïwenn Jacolot; Florence Popowycz

https://doi.org/10.1002/ejoc.202301119

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Herbicide detection: A review of enzyme- and cell-based biosensors

Octobre G., Delprat N., Doumèche B., Leca-Bouvier B.

Environ. Res. 2024, 249:118330

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SB-258585 reduces food motivation while blocking 5-HT6 receptors in the non-human primate striatum

M. Pitoy, L. Gauthier, J. Debatisse, J. Maulavé, E. Météreau, M. Beaudoin, K. Portier, V. Sgambato, T. Billard, L. Zimmer, S. Lancelot, L. Tremblay

Prog. Neuro-Psychopharmacol. Biol. Psychiatry 2024, 131, 110970

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