Chemistry at the interface with Biology and MedicineChimiothérapies tropicales

Our research is based on our medical and pharmaceutical background and a bed-to-bench strategy. The team has strong experience in malaria research, from basic sciences to applied diagnosis and treatment, including prospective clinical trials. The group is fully equipped to study clones of malaria parasites and isolates from patients leading to direct proof of concept of our research hypothesis. Among these, the effect of innovative single dose drugs on malaria transmission and disease severity is explored in the lab and during long-term prospective clinical trials in endemic west-African and Asian countries. We are also involved in antifungal stewardship aiming at an optimal use of antifungals through careful selection of agents based on patient profile, target organism, toxicity, cost, as well as the likelihood of emergence and spread of antifungal resistance. In that perspective, we are implementing stewardship programs in health care facilities to limit overuse or misuse of antifungals proven to be responsible for an increase in resistance.

Teams and groups Our teams

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Publications Find the most recent scientific contributions

Paper-based electrodes as a tool for detecting ligninolytic enzymatic activities

Fall, I., Doumèche, B., Abdellaoui, S., Rémond C., Rakotoarivonina, H., Ochs M.

Bioelectrochem. 2023, 156, 108609

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Synthetic outer membrane vesicles bearing Tn antigen

Carolina Chieffo, Arnaud Comte, Peter Strazewski and Michele Fiore*

European Journal of Organic Chemistry 2023

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Difluoromethoxylated Ketones as Building Blocks for the Synthesis of Challenging OCF2H-Bearing N-Heterocycles

A. Loison, G. Hanquet, F. Toulgoat, T. Billard, A. Panossian and F. R. Leroux

Eur. J. Org. Chem. 2023, 26, e202300695

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The origin and early evolution of life: homochirality emergence in prebiotic environments

Carolina Chieffo, Anastasiia Shvetsova, Fryni Skorda, Augustin Lopez, and Michele Fiore*

Astrobiology 2023, 23

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Identifying Potent Nonsense-Mediated mRNA Decay Inhibitors with a Novel Screening System

Julie Carrard , Fiona Ratajczak , Joséphine Elsens , Catherine Leroy , Rebekah Kong , Lucie Geoffroy , Arnaud Comte , Guy Fournet , Benoît Joseph , Xiubin Li , Sylvie Moebs-Sanchez, Fabrice Lejeune

Biomedicines 2023, 11(10), 2801

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