Chemistry at the interface with Biology and MedicineChimiothérapies tropicales

Our research is based on our medical and pharmaceutical background and a bed-to-bench strategy. The team has strong experience in malaria research, from basic sciences to applied diagnosis and treatment, including prospective clinical trials. The group is fully equipped to study clones of malaria parasites and isolates from patients leading to direct proof of concept of our research hypothesis. Among these, the effect of innovative single dose drugs on malaria transmission and disease severity is explored in the lab and during long-term prospective clinical trials in endemic west-African and Asian countries. We are also involved in antifungal stewardship aiming at an optimal use of antifungals through careful selection of agents based on patient profile, target organism, toxicity, cost, as well as the likelihood of emergence and spread of antifungal resistance. In that perspective, we are implementing stewardship programs in health care facilities to limit overuse or misuse of antifungals proven to be responsible for an increase in resistance.

Teams and groups Our teams

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Publications Find the most recent scientific contributions

How can we solve the problem of bioprintability to overcome the bioprinting challenges?

Alizée Mosnier, Imen Halima & Edwin-Joffrey Courtial

MRS Bulletin (2024)

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Unlocking the potential of bio-inspired bioinks: A collective breakthrough in mammalian tissue bioprinting

Marquette, C. A.; Chastagnier, L.; Da Sousa, B.; Chocarro-Wrona, C.; Courtial, E.-J.; Rae, E.; Thomann, C.; Carre, A.; Essayan, L.; Pasuch, A. J.; Mosnier, A.; Devillard, C.; Petiot, E.; Lemarié, L.; Matera, E.-L.; Simoes, M.; Dumontet, C.; Cuella Martin, C.; Pechtimaldjian, L.; Pécheur, E.-I.; Maguer-Satta, V.; Michelet, M.; Plissonnier, M.-L.; Archer, F.; Moreau, K.; Dufaud, M.; Zaupa, C.; Balloul, J.-M.; Pruvost, Q.; Dauphin, T.; Mosser, M.; Pragnère, S.,

Bioprinting, 2024, 41: e00351

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Space radiation damage rescued by inhibition of key spaceflight associated miRNAs

J. Tyson McDonald, Jang Keun Kim,Lily Farmerie,Meghan L. Johnson, Nidia S. Trovao, Shehbeel Arif, Keith Siew, Sergey Tsoy, Yaron Bram, Jiwoon Park,EliahOverbey,Krista Ryon, Jeffrey Haltom, Urminder Singh, Francisco J. Enguita, Victoria Zaksas, Joseph W. Guarnieri, Michael Topper, Douglas C. Wallace, Cem Meydan, Stephen Baylin, Robert Meller, Masafumi Muratani, D.Marshall Porterfield, Brett Kaufman, Marcelo A. Mori, Stephen B. Walsh, Dominique Sigaudo-Roussel, Saida Mebarek, Massimo Bottini, Christophe A. Marquette, Eve Syrkin Wurtele, Robert E. Schwartz, DiegoGaleano, Christopher E. Mason, Peter Grabham & Afshin Beheshti

Nat. Commun. 2024, 15: 4825

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Convergent synthesis of N-(4-(3-ethoxy-2-hydroxypropyl)phenyl)-2-(methylthio) acetamide precursor of the suplatast tosylate

Margherita Colombo, Yousef Joqmara, Guillaume Pilet, Michele Fiore

Trends in Organic Chemistry, 2024, 24, 79-92

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Biochemical, Bioinformatic, and Structural Comparisons of Transketolases and Position of Human Transketolase in the Enzyme Evolution

Biochemistry, 2024

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