For many years, the SMITh team has been devoted to the development of drug candidates and pharmacological tools, mainly in the field of cancer. The drug candidates are either small molecules (ALDH inhibitors) or antibody drug conjugates (ADC) using innovative technologies developped by SMITh team and partners. The pharmacological tools concern RNA binders (homocarbonyltopsentin - PK4C9 with application in spinal muscular atrophy), kinase inhibitors (finisterin and meriolin series as potent anticancer drugs) and transglutaminase inhibitors (BJJF078).

Notre équipe

forme_membres_ICBMS Guy Fournet

Guy Fournet

chargé de recherche cnrs

forme_membres_ICBMS Benoît Joseph

Benoît Joseph


Publications Retrouvez les dernières contributions

Monodisperse polysarcosine-based highly-loaded antibody-drug conjugates

Viricel, W.; Fournet, G.; Beaumel, S.; Perrial, E.; Papot, S.; Dumontet, C.; Joseph, B.

Chemical Science, 2019, 10(14), 4048-4053.

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Dual disruption of aldehyde dehydrogenases 1 and 3 promotes functional changes in the glutathione redox system and enhances chemosensitivity in nonsmall cell lung cancer

Rebollido-Rios, Rocio ; Venton, Geoffroy; Sanchez-Redondo, Sara; Iglesias i Felip, Carmela; Fournet, Guy ; Gonzalez, Elena; Romero Fernandez, Wilber; Borroto Escuela, Dasiel Oscar; Di Stefano, Barbara; Penarroche-Diaz, Reinier; Martin, Guillaume; Ceylan, Ismail; Costello, Regis; Perez-Alea, Mileidys

Oncogene, 2020, 39(13), 2756-2771

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Exatecan antibody drug conjugates based on a hydrophilic polysarcosine drug-linker platform

Conilh, Louise; Fournet, Guy; Fourmaux, Eric; Murcia, Angelique; Matera, Eva-Laure; Joseph, Benoit; Dumontet, Charles; Viricel, Warren

Pharmaceuticals, 2021, 14(3), 247.

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Targeting RNA structure in SMN2 reverses spinal muscular atrophy molecular phenotypes

Garcia-Lopez, A.; Tessaro, F.; Jonker, Hendrik R. A.; Wacker, A.; Richter, C.; Comte, A.; Berntenis, N.; Schmucki, R.; Hatje, K.; Petermann, O.; Chiriano, G.; Perozzo, R; Sciarra, D.; Konieczny, K.; Faustino, I.; Fournet, G.; Orozco, M.; Metzger, F.; Ebeling, M.; Goekjian, P.; Joseph, B.; Schwalbe, H.; Scapozza, L.

Nature Communications, 2019, 9(1), 1-12

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Access to cyclic gem-difluoroacyl scaffolds via electrochemical and visible light photocatalytic radical tandem cyclization of heteroaryl chlorodifluoromethyl ketones

C. Adouama, R. Keyrouz, G. Pilet, C. Monnereau, D. Gueyrard, T. Noel, M. Médebielle*

Chem. Commun., 2017, 53, 5653-5656.

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