Mme Laurence BESSUEILLE

Bio

Laurence Bessueille studied at Aix-Marseille University where she obtained her PhD in Biochemistry and Molecular Biology in 1989 under the supervision of Pr Louis Sarda. She then completed a two-year post-doctoral internship at Mallinckrot Medical Inc, (Saint Louis, USA), followed by one year at the Enzymatic Lipolysis Laboratory (CNRS-ERS26, Marseille). She was recruited as an associate professor at UCBL in 1993 and joined the MEM2 team at ICBMS in 2010 where she is in charge of the technical, experimental and logistical aspects of vascular calcification projects.

Research interests

Her research interests are centered on the role of alkaline phosphatase in physiological and pathological calcification mechanisms, in particular in the development of vascular calcifications.

Selected publications

Inhibition of alkaline phosphatase impairs dyslipidemia and protects mice from atherosclerosis.

Bessueille L, Kawtharany L, Quillard T, Goettsch C, Briolay A, Taraconat N, Balayssac S, Gilard V, Mebarek S, Peyruchaud O, Duboeuf F, Bouillot C, Pinkerton A, Mechtouff L, Buchet R, Hamade E, Zibara K, Fonta C, Canet-Soulas E, Millan JL, Magne D. Transl Res. 2022 Jun 17:S1931-5244(22)00144-X.

TNAP as a therapeutic target for cardiovascular calcification: a discussion of its pleiotropic functions in the body.

Goettsch C, Strzelecka-Kiliszek A, Bessueille L, Quillard T, Mechtouff L, Pikula S, Canet-Soulas E, Millan JL, Fonta C, Magne D. Cardiovasc Res. 2022 Jan 7;118(1):84-96.

Tissue-nonspecific alkaline phosphatase is an anti-inflammatory nucleotidase.

Bessueille L, Briolay A, Como J, Mebarek S, Mansouri C, Gleizes M, El Jamal A, Buchet R, Dumontet C, Matera EL, Mornet E, Millan JL, Fonta C, Magne D. Bone. 2020 Apr;133:115262.