Research areaBiochemistry and Molecular Biology
The main research themes of the Biochemistry and Molecular Biology cluster of the ICBMS extend to the understanding of molecular mechanisms and the mechanisms of interactions between biomolecules and cellular components, in particular:
- Regulation of enzyme expression and activity and their link to the metabolic syndrome, with emphasis on alkaline phosphatase, phospholipase D and sphingosine kinase in the process of tissue calcification and ossification.
- Characterization of the structure-interactions-functions of extracellular matrix with a focus on intrinsically disordered extracellular proteins and proteoglycans, and on glycosaminoglycans.
- The understanding and use of the mechanisms of interactions between biomolecules or cellular components with electrochemical, optical and/or 3D materials while keeping the understanding of biochemical phenomena as a framework.
Research topics ICBMS expertises
Publications Find the most recent scientific contributions
Herbicide detection: A review of enzyme- and cell-based biosensors
Octobre G., Delprat N., Doumèche B., Leca-Bouvier B.
Environ. Res. 2024, 249:118330
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From the RNA-Peptide World: Prebiotic reaction conditions compatible with lipid membranes for the formation of lipophilic random peptides in the presence of short oligonucleotides, and more
Augustin Lopez, Antoine Vauchez, Ghinwa Ajram, Anastasiia Shvetsova, Gabrielle Leveau, Michele Fiore, Peter Strazewski*
Life 2024, 14, 108
Read the whole publicationDo Media Extracellular Vesicles and Extracellular Vesicles Bound to the Extracellular Matrix Represent Distinct Types of Vesicles?
Mebarek S, Buchet R, Pikula S, Strzelecka-Kiliszek A, Brizuela L, Corti G, Collacchi F, Anghieri G, Magrini A, Ciancaglini P, Millan JL, Davies O, Bottini M
Biomolecules . 2023 Dec 28;14(1):42
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Structural determination and kinetic analysis of the Transketolase from Vibrio vulnificus reveal unexpected cooperative behavior.
Georges, R.-N., Ballut, L., Octobre, B., Comte, A., Hecquet, L., Charmantray, F.*, Doumèche, B.
Protein Science, 2024, 33(3):e4884
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Paper-based electrodes as a tool for detecting ligninolytic enzymatic activities
Fall, I., Doumèche, B., Abdellaoui, S., Rémond C., Rakotoarivonina, H., Ochs M.