Research areaBiochemistry and Molecular Biology

The main research themes of the Biochemistry and Molecular Biology cluster of the ICBMS extend to the understanding of molecular mechanisms and the mechanisms of interactions between biomolecules and cellular components, in particular:

  • Regulation of enzyme expression and activity and their link to the metabolic syndrome, with emphasis on alkaline phosphatase, phospholipase D and sphingosine kinase in the process of tissue calcification and ossification.
  • Characterization of the structure-interactions-functions of extracellular matrix with a focus on intrinsically disordered extracellular proteins and proteoglycans, and on glycosaminoglycans.
  • The understanding and use of the mechanisms of interactions between biomolecules or cellular components with electrochemical, optical and/or 3D materials while keeping the understanding of biochemical phenomena as a framework.

Research topics ICBMS expertises

Mechanisms and understanding of biomolecules and cellular components’ interactions with electrochemical, optical and 3D polymeric materials.

Biochemistry and Molecular Biology

Molecular mecanisms of mineralization

Biochemistry and Molecular Biology


Biochemistry and Molecular Biology


Biochemistry and Molecular Biology

Teams and groups Our teams

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Publications Find the most recent scientific contributions

User-friendly one-step disposable signal-on bioassay for glyphosate detection in water samples

Delprat, N., Martins, L.O., Blum, L.J., Aymard, C.M.G., Leca-Bouvier, B., Octobre, G., Doumèche, B.

Biosens. Bioelecton. 2023, 241, 115689

Microwave-assisted syntheses of rhodamine, rhodol, and fluorescein derivatives

Carolina Chieffo, Emiliano Altamura, Guillaume Pilet, Saïda Mebarek, Peter Strazewski and Michele Fiore*

ChemPlusChem 2023, 88, e202300189

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Deciphering dynamic combinatorial libraries of glycoclusters with miniaturized weak affinity chromatography coupled with mass spectrometry (nano-FAC-MS)

F. Jeanroy, F. Demontrond, F. X. Vidal, D. Gueyrard, S. Vidal, C. Demesmay, V. Dugas

Analytica Chimica Acta, 2023, 1261, 341227

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Glycosaminoglycans: What Remains To Be Deciphered?

Serge Perez,* Olga Makshakova, Jesus Angulo, Emiliano Bedini, Antonella Bisio, Jose Luis de Paz, Elisa Fadda, Marco Guerrini, Michal Hricovini, Milos Hricovini, Frederique Lisacek, Pedro M. Nieto, Kevin Pagel, Giulia Pairardi, Ralf Richter, Sergey A. Samsonov, Romain A. Vivès, Dragana Nikitovic, and Sylvie Ricard Blum

JACS Au 2023 (ASAP)

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How Warburg-Associated Lactic Acidosis Rewires Cancer Cell Energy Metabolism to Resist Glucose Deprivation

Daverio, Z., Balcerczyk, A., Rautureau, G.J.P., Panthu, B.

Cancers 2023, 15, 1417.

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