LCO2

The Laboratoire de Chimie Organique 2 is a team composed of three independently publishing research groups: "Methodology and Synthesis", "Systems Chemistry" and "Biological Membranes".

The members of each research group collaborate in the team and complement each others scientific work with know-how and instrumentation specific to each group.

    

  

  

 

forme_membres_ICBMS Francis AGWOM

Francis AGWOM

PhD Student

forme_membres_ICBMS Layth BEN TRAD

Layth BEN TRAD

Doctor and Temporary Teaching and Research Attaché

forme_membres_ICBMS Anna BEROT

Anna BEROT

PhD student

forme_membres_ICBMS Michele FIORE

Michele FIORE

Associate Professor

forme_membres_ICBMS Peter GOEKJIAN

Peter GOEKJIAN

Professor

forme_membres_ICBMS Thierry Granjon

Thierry Granjon

Associate Professor

forme_membres_ICBMS David GUEYRARD

David GUEYRARD

Professor, LCO2 team leader

forme_membres_ICBMS Francesco Mariani

Francesco Mariani

M2 Student

forme_membres_ICBMS Noémie  Murard

Noémie Murard

M2 Student

forme_membres_ICBMS Anastasiia SHVETSOVA

Anastasiia SHVETSOVA

Doctor, Alumna since 18 December 2023

forme_membres_ICBMS Pierre Strazewski

Pierre Strazewski

Professor

forme_membres_ICBMS Andrea  TERZI

Andrea TERZI

PhD student

The Methodology and Synthesis group focuses on carbohydrate chemistry in a very broad sense, from total synthesis, methodology, and the synthesis of biologically active glycomimetics, such as ATP-competitive kinase inhibitors, multivalent systems, carbohydrate-based peptidomimetics, glycosidase inhibitors, biological probes, etc. We specialize in developping novel methodologies and in the synthesis of biologically relevant molecules and natural products. Methodologies and total syntheses are usually initially applied to carbohydrate targets and structures, but we make a conscious effort to extend these methodologies beyond carbohydrates.

forme_membres_ICBMS Francis AGWOM

Francis AGWOM

PhD Student

forme_membres_ICBMS Peter GOEKJIAN

Peter GOEKJIAN

Professor

forme_membres_ICBMS David GUEYRARD

David GUEYRARD

Professor, LCO2 team leader

forme_membres_ICBMS Francesco Mariani

Francesco Mariani

M2 Student

forme_membres_ICBMS Noémie  Murard

Noémie Murard

M2 Student

forme_membres_ICBMS Andrea  TERZI

Andrea TERZI

PhD student

SysChem stands for "systems chemistry of biomolecules and prebiotic chemistry". We are generally studying the systemic interactions between synthetic lipophilic peptides, synthetic nucleic acids and racemic, scalemic or natural phospholipids to approach the self-evolution of synthetic living cells. The growth and division of giant phospholipid vesicles is one major research topic. We are studying the mechanism and scope of the phosphorylation of alkanols, nucleosides and glycerols under prebiotic conditions. We also engage in developing synthetic vaccines based on glycolipid vesicles.

More about the SysChem group members and recent publications at: https://www.icbms.fr/en/team/20-lco2-html

forme_membres_ICBMS Michele FIORE

Michele FIORE

Associate Professor

forme_membres_ICBMS Anastasiia SHVETSOVA

Anastasiia SHVETSOVA

Doctor, Alumna since 18 December 2023

forme_membres_ICBMS Pierre Strazewski

Pierre Strazewski

Professor

The Biological Membranes Group analyses the molecular, structural and mechanistic bases of biological functions by using standard biochemistry techniques (expression and purification of recombinant enzymes, biochemical characterization of these enzymes, study of the structure-function relationships of these molecules, study of protein-ligand and protein-membrane interactions, lipidomics), at the level of both proteins and lipids but also by developing multidisciplinary approaches at the interfaces with Chemistry, Physics and Biology (study of the dynamics and organization of biological membranes under physiological or pathological conditions, development of new fluorescence tools in spectroscopy and microscopy, Fourier transform infrared spectroscopy, polarization modulation-infrared reflection-adsorption spectroscopy, Brewster angle microscopy, rheological and tribological properties of biomimetic or natural vesicles...), purification and characterization of various extracellular vesicles (exosomes, matrix vesicles, synovial vesicles).

In this perspective, several biological models are studied/used ranging from liposomes, lipid monolayers, lipid bilayers to cells.

Two topics are particularly developed (2 theses are in progress) related to the study of the dynamics of biological membranes through the use of fluorescence probes developed in the team. One thesis concerns the "Biophysicochemical characterization of cell membranes during tumorigenesis", with an application to breast and prostate cancer, the other is interested in joint pathologies and is entitled "Role of membrane fluidity in the behavior of synovial vesicles from healthy and pathological sampling ".

forme_membres_ICBMS Layth BEN TRAD

Layth BEN TRAD

Doctor and Temporary Teaching and Research Attaché

forme_membres_ICBMS Anna BEROT

Anna BEROT

PhD student

forme_membres_ICBMS Thierry Granjon

Thierry Granjon

Associate Professor

Publications Find the most recent scientific contributions

From the RNA-Peptide World: Prebiotic reaction conditions compatible with lipid membranes for the formation of lipophilic random peptides in the presence of short oligonucleotides, and more

Augustin Lopez, Antoine Vauchez, Ghinwa Ajram, Anastasiia Shvetsova, Gabrielle Leveau, Michele Fiore, Peter Strazewski*

Life 2024, 14, 108

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Synthetic outer membrane vesicles bearing Tn antigen

Carolina Chieffo, Arnaud Comte, Peter Strazewski and Michele Fiore*

European Journal of Organic Chemistry 2023, 26, e202300820

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The origin and early evolution of life: homochirality emergence in prebiotic environments

Carolina Chieffo, Anastasiia Shvetsova, Fryni Skorda, Augustin Lopez, and Michele Fiore*

Astrobiology 2023, 23

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Evaluation of Nonnatural L-Iminosugar C,C-Glycosides, a New Class of C-Branched Iminosugars, as Glycosidase Inhibitors

Jérôme Désiré, Zakaria Debbah, David Gueyrard, Jérôme Marrot, Yves Blériot and Atsushi Kato

Carbohydr. Res. 2023, 532, 108903

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Microwave-assisted syntheses of rhodamine, rhodol, and fluorescein derivatives

Carolina Chieffo, Emiliano Altamura, Guillaume Pilet, Saïda Mebarek, Peter Strazewski and Michele Fiore*

ChemPlusChem 2023, 88, e202300189

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