Our research is based on our medical and pharmaceutical background and a bed-to-bench strategy. The team has strong experience in malaria research, from basic sciences to applied diagnosis and treatment, including prospective clinical trials. The group is fully equipped to study clones of malaria parasites and isolates from patients leading to direct proof of concept of our research hypothesis. Among these, the effect of innovative single dose drugs on malaria transmission and disease severity is explored in the lab and during long-term prospective clinical trials in endemic west-African and Asian countries. We are also involved in antifungal stewardship aiming at an optimal use of antifungals through careful selection of agents based on patient profile, target organism, toxicity, cost, as well as the likelihood of emergence and spread of antifungal resistance. In that perspective, we are implementing stewardship programs in health care facilities to limit overuse or misuse of antifungals proven to be responsible for an increase in resistance.

Our team

forme_membres_ICBMS Anne-Lise BIENVENU


Co principal investigator

forme_membres_ICBMS Ibrahim BIN SA'ID

Ibrahim BIN SA'ID

PhD student

forme_membres_ICBMS Guillaume BONNOT

Guillaume BONNOT

forme_membres_ICBMS Régine FERREIRA


forme_membres_ICBMS Yobouet Ines KOUAKOU

Yobouet Ines KOUAKOU

PhD Student

forme_membres_ICBMS Roukayatou OMOROU

Roukayatou OMOROU

PhD student

forme_membres_ICBMS Stephane PICOT

Stephane PICOT


Publications Find the most recent scientific contributions

Structural and molecular determinants of Candida glabrata metacaspase maturation and activation by calcium

Conchou, L.; Doumèche, B; Galisson, F.; Violot, S.; Dugelay, C.; Diesis, E.; Page, A.; Bienvenu, A.-L.; Picot, S.;Aghajari, N. and Ballut L.

Commun. Biol. 2022, 5, 1158

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Pre-referral intranasal artesunate powder for cerebral malaria: a proof-of-concept study

Yobouet Ines Kouakou, Aurelien Millet, Elodie Fromentin, Nathalie Hauchard, Gonçalo Farias, Maxime Fieux, Aurelie Coudert, Roukayatou Omorou, Ibrahim Bin Sa’id, Adeline Lavoignat, Guillaume Bonnot, Anne-Lise Bienvenu & Stephane Picot

Malaria Journal, 2022, 21, 291

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Evaluation of ferrocenyl-containing γ-hydroxy-γ-lactam-derived tetramates as potential antiplasmodials

Nicolas Chopin , Julien Bosson , Shinya Iikawa , Stéphane Picot , Anne-Lise Bienvenu , Adeline Lavoignat , Guillaume Bonnot , Mickael Riou , Corinne Beaugé , Vanaïque Guillory , Christophe Biot , Guillaume Pilet , Matthieu Chessé , Elisabeth Davioud-Charvet , Mourad Elhabiri , Jean-Philippe Bouillon, Maurice Médebielle

Eur J Med Chem . 2022 Sep 12;243:114735

Paper functionalization for detection of Plasmodium falciparum DNA using square waves voltammetry

Romain Clément , Anne-Lise Bienvenu , Adeline Lavoignat , Guillaume Bonnot , Bastien Doumèche , Stéphane Picot

Talanta . 2022 Aug 18;252:123839.

The first case of artemisinin treatment failure of plasmodium falciparum imported to Oman from Tanzania

Amit Kumar Subudhi , Anne-Lise Bienvenu , Guillaume Bonnot, Reem Abu-Shamma , Faryal Khamis , Hussain Ali Abdulhussain Al Lawati , Stephane Picot , Eskild Petersen , Arnab Pain

J Travel Med . 2022 Aug 12;taac092. doi: 10.1093/jtm/taac092. Online ahead of print.

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