COB
Organic and Bioorganic Chemistry
The team develops research projects aiming at designing innovative synthetic tools and molecular architectures, based on expertise in homogeneous catalysis, carbohydrate chemistry and heterocyclic chemistry. Projects are conducted within national and international academic or industrial collaborations and partnerships with applications to :
- biobased and sustainable chemistry
- synthetic methodology and catalysis *
- the interface of life sciences.
biobased and sustainable chemistry,
recent projects concern the chemistry of furanic platform molecules, aiming at diversifying the molecular design of biobased chemicals while overcoming reactivity and selectivity issues.
synthetic methodology and catalysis,
the projects aims at developing synthetic methodology towards molecules of biological relevance as well as innovation towards biobased chemicals (N or C borrowing hydrogen). Applications range from low- or medium-added value products such as surfactants or polymers, to more elaborated systems such as organocatalysts or molecular scaffolds for fine chemistry.
interface of life sciences,
the team is involved in methodological explorations of biomolecular interactions (carbohydrates, lipids and heterocycles) at the synthetic and physico-chemical level and in projects aiming at the rational design of biologically relevant targets including probes dedicated to the study of biological and biochemical mechanisms and biologically active molecules with antibacterial, pesticide, rodenticide activities.
Our team
Publications Find the most recent scientific contributions
Machine learning approaches for the identification of ligands of the autophagy marker LC3
Laurent Soulère, Yves Queneau
Artificial Intelligence Chemistry 1(2) (2023) 100022
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Importance of the 2,6-Difluorobenzamide Motif for FtsZ Allosteric Inhibition: Insights from Conformational Analysis, Molecular Docking and Structural Modifications
T. Barbier, O. Dumitrescu, G. Lina, Y. Queneau, L. Soulère
Molecules, 2023, 28(5), 2055
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Access to Saturated Aza-Heterocycles using the Borrowing Hydrogen Methodology
Maïwenn Jacolot; Florence Popowycz
https://doi.org/10.1002/ejoc.202301119
Read the whole publicationIdentifying Potent Nonsense-Mediated mRNA Decay Inhibitors with a Novel Screening System
Julie Carrard , Fiona Ratajczak , Joséphine Elsens , Catherine Leroy , Rebekah Kong , Lucie Geoffroy , Arnaud Comte , Guy Fournet , Benoît Joseph , Xiubin Li , Sylvie Moebs-Sanchez, Fabrice Lejeune
Biomedicines 2023, 11(10), 2801
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Ir–Na cooperativity controls the diastereoselectivity of borrowing hydrogen C–C alkylation on isosorbide: synthesis methodology and mechanistic investigation
Jordan François, Jordan Rio, Erwann Jeanneau, Marie-Ève L. Perrin, Maïwenn Jacolot, Pierre-Adrien Payard and Florence Popowycz