Research areaChemistry at the interface with Biology and Medicine
Some of the ICBMS teams work at the interface between chemistry and life sciences. Their applications are related to medicinal chemistry, particularly in the field of infectiology, oncology and medical imaging, or aspects aimed at a better understanding of biochemical processes such as membrane properties and cell functions, metabolic processes, but also prebiotic chemistry, self-evolving chemical systems and the development of synthetic vaccines based on glycolipid vesicles. To achieve this objective, the researchers use their expertise to develop various innovative tools as well as cross and multidisciplinary approaches, combining theory and experiments, biomimetic systems, molecular probes and selective enzyme inhibitors.
Research topics ICBMS expertises
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Publications Find the most recent scientific contributions
Deep Study of Thiocarbamoyl Fluorides: Synthesis and Properties
Clément Delobel, Emmanuel Chefdeville, Fabien Toulgoat, Thierry Billard
C. Delobel, E. Chefdeville, F. Toulgoat, T. Billard, Adv. Synth. Catal. 2024, 366, 3474-3480.
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Targeting the Complexity of In Vitro Skin Models: A Review of Cutting-Edge Developments
Quilez C., Bebiano L.B., Jones E., Maver U., Meesters L., Parzymies P., Petiot E., Rikken G., Risueno I., Zaidi H., Zidaric T., Bekeschus S., van den Bogaard E.H., Caley M., Colley H., Lopez N.G., Letsiou S., Marquette C., Maver T., Pereira R.F., Tobin D.J., Velasco D.
Journal of Investigative Dermatology (2024), in press
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WAY-208466, a 5-HT6 receptor agonist, increases food motivation in primates: A behavioural and PET imaging study opening perspectives in eating disorders
M. Pitoy, J. Maulavé, L. Gauthier, J. Debatisse, N. Costes, I. Mérida, T. Billard, K. Portier, S. Lancelot, B. Galusca, L. Zimmer, L. Tremblay
Neuroscience Applied 2024, 3, 104086
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Trifluoromethoxylation of Arynes Using 2,4-Dinitro-1-(trifluoromethoxybenzene) as Trifluoromethoxide Anion Source
L. Wisson, G. Hanquet, F. Toulgoat, T. Billard, A. Panossian, F. R. Leroux
Eur. J. Org. Chem. 2024, 27, e202400388
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3D bioprinted CRC model brings to light the replication necessity of an oncolytic vaccinia virus encoding FCU1 gene to exert an efficient anti-tumoral activity
Marquette CA, Petiot E, Spindler A, Ebel C, Nzepa M, Moreau B, Erbs P, Balloul J-M, Quemeneur E and Zaupa C