COnception & Synthesis of Biologically Active Substances

COSSBA | LinkedIn

Members of COSSBA team (COnception & Synthesis of Biologically Active Substances) have an expertise in medicinal chemistry to develop molecules with potential therapeutic interests in cancerology (kinases' inhibitors and tubuline polymerization inhibitors) and infectiology (antibacterial agents or molecules targeting viral proteins). By combining pharmacomodulation approaches of various molecular scaffolds (inspired by different chemical series or by natural products) and interaction studies between the target protein and ligands using physicochemical techniques (such as NMR, Mass Spectrometry...), new chemical entities are identified and evaluated by our biologists partners. A part of our researches are also dedicated to synthetic methodology of chemical structures relevant in medicinal chemistry (mainly heterocycles), which are thereafter incorporated in molecular targets of our Drug Design projects.


COSSBA Breaking News - January 2023

Our colleague Amanda GARRIDO is one of the winner of the call for projects ACCUEIL 2023 of Claude Bernard Lyon 1 University, which will allow her to continue the development of new antibacterial agents. This is an IRRESTIBLE project! Innovation and Research of new chemical entities to fight antimicrobial RESISTance thanks to innovative targets.


COSSBA Breaking News - July 2023

The LinkedIn page of the COSSBA team is created! Do not hesitate to follow our different posts by clicking on the link of the the home page!

forme_membres_ICBMS Mandy AYMARD


PhD student

forme_membres_ICBMS Laurent ETTOUATI


Associate professor

forme_membres_ICBMS Amanda GARRIDO


Assistant professor

forme_membres_ICBMS Ali HADDANE


Engineering assistant

forme_membres_ICBMS François HALLÉ

François HALLÉ

Assistant professor

forme_membres_ICBMS Thierry LOMBERGET


Full professor

forme_membres_ICBMS Marine ORTILLON


PhD student

forme_membres_ICBMS Sylvie RADIX

Sylvie RADIX

Associate professor

forme_membres_ICBMS Luc ROCHEBLAVE


Associate professor

forme_membres_ICBMS Jean ROUSSEL


PhD student

The COSSBA team develops synthetic methodologies to prepare and functionnalize various chemical series with marked interest in medicinal chemistry: azaindoles, benzimidazoles, imidazopyridin(on)es, (dihydro)benzofuranes.

Publications Find the most recent scientific contributions

Cancer selective cell death induction by a bivalent CK2 inhibitor targeting the ATP site and the allosteric αD pocket

Alexandre Bancet, Rita Frem, Florian Jeanneret, Angélique Mularoni, Pauline Bazelle, Caroline Roelants, Jean-Guy Delcros, Jean-François Guichou, Catherine Pillet, Isabelle Coste, Toufic Renno, Christophe Battail, Claude Cochet, Thierry Lomberget, Odile Filhol, Isabelle Krimm

iScience 2024, 27, 108903

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Pharmacomodulation of a ligand targeting the HBV capsid hydrophobic pocket

Mathilde Briday, François Hallé, Lauriane Lecoq*, Sylvie Radix, Juliette Martin, Roland Montserret, Marie Dujardin, Marie-Laure Fogeron, Michael Nassal, Beat H. Meier, Thierry Lomberget*, Anja Böckmann*

Chem. Sci. 2022, 13, 8840-8847

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4,5,7-Trisubstituted indeno[1,2-b]indole inhibits CK2 activity in tumor cells equivalent to CX-4945 and shows strong anti-migratory effects

Robin Birus, Ehab El-Awaad, Laurens Ballentin, Faten Alchab, Dagmar Aichele, Laurent Ettouati, Claudia Götz, Marc Le Borgne, Joachim Jose*

FEBS Open Bio 2022, 12, 394–411

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A journey through Hemetsberger-Knittel, Leimgruber-Batcho and Bartoli reactions: access to several hydroxy 5- and 6-azaindoles

Sylvie Radix, François Hallé, Zahia Mahiout, Amélie Teissonnière, Grégoire Bouchez, Ludovic Auberger, Roland Barret, Thierry Lomberget*

Helv. Chim. Acta 2022, 105, e202100211.

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Combretastatin A-4 sulfur-containing heterocyclic derivatives: synthesis, antiproliferative activities and molecular docking studies

Abdelfattah Faouzi, Alexandre Arnaud, Alexandre Bancet, Caroline Barette, Jordane Preto, Cong Viet Do, Lars Petter Jordheim, Zineb Bousfiha, Thi Thanh Binh Nguyen, Marion Verrière, Amaury Farce, Marie-Odile Fauvarque, Roland Barret, Thierry Lomberget*

Eur. J. Med. Chem. 2021, 215, 113275

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