François Hallé earned a PhD in Chemical Biology in 2015, developing heterocyclic and peptidic ligands for the Translocator Protein (TSPO) and evaluate their activities in cellular models of Alzheimer disease. This work was performed at Laboratoire d’Innovation Thérapeutique (UMR7200 - University of Strasbourg) and supervised by Dr. Frédéric Bihel and Dr. Martine Schmitt. It allowed him to develop skills in heterocyclic and peptide chemistry, as well as in cell culture and biological evaluation in Alzheimer Disease in vitro models through collaboration with Neurobiological Laboratory of Basel (Head : Anne Eckert).
He was then awarded with a Fulbright grant to spend a year post-doc in Yitzhak Tor Lab (University California San Diego - UCSD, California), where he successfully developed fluorescent analogues of NAD, NADH, NADP and NADPH and their interplays in multiple enzymatic reactions. During this post-doc, he also worked on the development of liposomes bearing guanidinylated neomycin and their uptake in different cell lines, improving his knowledge his cell culture and in vitro experiments skills.
His implication as a temporary teaching assistant (ATER) in Bordeaux University in the team of Jean Guillon (ARNA Team - Inserm U1212) was his first involvement in the development of kinase inhibitors.
His last post-doc experience was within Dr. Gilles Guichard Peptidomimetic group in IECB (UMR5248 - CBMN - Bordeaux).
He was appointed Assistant Professor at the Faculty of Pharmacy (ISPB) of University Claude Bernard Lyon 1 in September 2019 in the COSSBA team (UMR5246 - ICBMS), leaded by Pr. Thierry Lomberget and focusing to develop chemically active substances in cancerology and infectiology fields.
Infectiology: HBV capside ligands
Cancerology: CK2 inhibitors
Neurology: Kinase inhibitors in Alzheimer disease
Chemical Biology: efflux pumps and molecular probes
- Pharmacomodulation of a ligand targeting the HBV capsid hydrophobic pocket.
Briday, M.; Hallé, F.; Lecoq, L.; Radix, S.; Martin, J.; Montserret, R.; Dujardin, M.; Fogeron, M-L.; Nassal, M.; Meier, B. H.; Lomberget T.; Böckmann, A. Chem. Sci. 2022, 13, 8840–8847.
- Emissive Synthetic Cofactors: Enzymatic Interconversions of tzA Analogues of ATP, NAD+, NADH, NADP+, and NADPH.
Hallé, F.; Fin, A.; Rovira, A. R.; Tor, Y. Angew. Chem. Int. Ed. 2018, 57, 1087–1090.
- TSPO Ligands Boost Mitochondrial Function and Pregnenolone Synthesis.
Lejri, I.; Grimm, A.; Hallé, F.; Abarghaz, M.; Klein, C.; Maitre, M.; Schmitt, M.; Bourguignon, J.-J.; Mensah Nyagan, A. G.; Bihel, F.; Eckert, A. J. Alzheimer's Dis. 2019, 72, 1045–1058.
Mathilde Briday, François Hallé, Lauriane Lecoq*, Sylvie Radix, Juliette Martin, Roland Montserret, Marie Dujardin, Marie-Laure Fogeron, Michael Nassal, Beat H. Meier, Thierry Lomberget*, Anja Böckmann*
Sylvie Radix, François Hallé, Zahia Mahiout, Amélie Teissonnière, Grégoire Bouchez, Ludovic Auberger, Roland Barret, Thierry Lomberget*