SURCOOF
Synthesis, Use, Reactivity of Organic and Organofluorinated Compounds
The research in the SURCOOF group concerns two aspects:
(1)
The development of new strategies to synthesize compounds bearing new Emerging Fluorinated groups with specific properties, in particular for potential applications in medicinal chemistry. These methods are also applied in radiochemistry to obtain radiotracers labeled with fluorine-18 for medical imaging applications (in collaboration with CERMEP platform)
(2)
The synthesis of natural complexe molecules with unusual skeleta using photochemistry (conventionnal or photoredox processes), metathesis and other organometallic and organocatalyzed reactions performed in non standard media or activation (e.g. FBS, ionic liquids,…) with an emphasis for 3 component reactions and economy of steps and atoms.
Our team
Our group develops new reagents and new methods to introduce emerging fluorinated moieties onto organic compounds. In particular, the association of fluoroalkyl groups and chalcogenes has been developed and studied in the last years. Thus, new reagents allowing the introduction of CF3O, CF3S, CF3Se moities have been described. Moreover, the properties, such as the lipophilicity, of these various groups are measured.
Member of GIS-Fluor
Publications Find the most recent scientific contributions
Unlocking the Power of Acyl Fluorides: A Comprehensive Guide to Synthesis and Properties
Clémence Bonnefoy, Adrien Gallego, Clément Delobel, Betty Raynal, Maxime Decourt, Emmanuel Chefdeville, Gilles Hanquet, Armen Panossian, Frédéric R. Leroux, Fabien Toulgoat, Thierry Billard
Eur. J. Org. Chem. 2024, 27, e202400142
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SB-258585 reduces food motivation while blocking 5-HT6 receptors in the non-human primate striatum
M. Pitoy, L. Gauthier, J. Debatisse, J. Maulavé, E. Météreau, M. Beaudoin, K. Portier, V. Sgambato, T. Billard, L. Zimmer, S. Lancelot, L. Tremblay
Prog. Neuro-Psychopharmacol. Biol. Psychiatry 2024, 131, 110970
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Difluoromethoxylated Ketones as Building Blocks for the Synthesis of Challenging OCF2H-Bearing N-Heterocycles
A. Loison, G. Hanquet, F. Toulgoat, T. Billard, A. Panossian and F. R. Leroux
Eur. J. Org. Chem. 2023, 26, e202300695
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Comprehensive Study and Development of a Metal-Free and Mild Nucleophilic Trifluoromethoxylation.
Clémence Bonnefoy, Armen Panossian, Gilles Hanquet, Frédéric R. Leroux, Fabien Toulgoat, Thierry Billard
Chem. Eur. J. 2023, 29, e202301513
Read the whole publicationOrganozinc reagents and nickel
O. Piva