The research in the SURCOOF group concerns two aspects:
The development of new strategies to synthesize compounds bearing new Emerging Fluorinated groups with specific properties, in particular for potential applications in medicinal chemistry. These methods are also applied in radiochemistry to obtain radiotracers labeled with fluorine-18 for medical imaging applications (in collaboration with CERMEP platform)
The synthesis of natural complexe molecules with unusual skeleta using photochemistry (conventionnal or photoredox processes), metathesis and other organometallic and organocatalyzed reactions performed in non standard media or activation (e.g. FBS, ionic liquids,…) with an emphasis for 3 component reactions and economy of steps and atoms.
Our group develops new reagents and new methods to introduce emerging fluorinated moieties onto organic compounds. In particular, the association of fluoroalkyl groups and chalcogenes has been developed and studied in the last years. Thus, new reagents allowing the introduction of CF3O, CF3S, CF3Se moities have been described. Moreover, the properties, such as the lipophilicity, of these various groups are measured.
Member of GIS-Fluor
Clémence Bonnefoy, Armen Panossian, Gilles Hanquet, Frédéric R. Leroux, Fabien Toulgoat, Thierry Billard
A. de Zordo-Banliat, K. Grollier, N. Vanthuyne, S. Floquet, Th. Billard, G. Dagousset, B. Pégot, E. Magnier
A. Loison, G. Hanquet, F. Toulgoat, T. Billard, A. Panossian, F. R. Leroux
Youssef Nassar, Fabienne Fache, Béatrice Pelotier, Olivier Piva