SURCOOF

Synthesis, Use, Reactivity of Organic and Organofluorinated Compounds

The research in the SURCOOF group concerns two aspects:

(1)

The development of new strategies to synthesize compounds bearing new Emerging Fluorinated groups with specific properties, in particular for potential applications in medicinal chemistry. These methods are also applied in radiochemistry to obtain radiotracers labeled with fluorine-18 for medical imaging applications (in collaboration with CERMEP platform)

(2)

The synthesis of natural complexe molecules with unusual skeleta using photochemistry (conventionnal or photoredox processes), metathesis and other organometallic and organocatalyzed reactions performed in non standard media or activation (e.g. FBS, ionic liquids,…) with an emphasis for 3 component reactions and economy of steps and atoms.

forme_membres_ICBMS Thierry BILLARD

Thierry BILLARD

CNRS research director

forme_membres_ICBMS Clémence Bonnefoy

Clémence Bonnefoy

PhD Student

forme_membres_ICBMS Fabienne FACHE

Fabienne FACHE

forme_membres_ICBMS Béatrice PELOTIER

Béatrice PELOTIER

forme_membres_ICBMS Olivier PIVA

Olivier PIVA

Professor and Head of ICBMS

forme_membres_ICBMS Fabien  TOULGOAT

Fabien TOULGOAT

Our group develops new reagents and new methods to introduce emerging fluorinated moieties onto organic compounds. In particular, the association of fluoroalkyl groups and chalcogenes has been developed and studied in the last years. Thus, new reagents allowing the introduction of CF3O, CF3S, CF3Se moities have been described. Moreover, the properties, such as the lipophilicity, of these various groups are measured.

Member of GIS-Fluor

forme_membres_ICBMS Thierry BILLARD

Thierry BILLARD

CNRS research director

forme_membres_ICBMS Clémence Bonnefoy

Clémence Bonnefoy

PhD Student

forme_membres_ICBMS Fabien  TOULGOAT

Fabien TOULGOAT

Our group is interested in the synthesis of bioactive molecules by taking advantage of previously developed synthetic methodologies. The structures involved 5- or 6-chain lactone patterns, macrolides or tetrahydropyrans which could be obtained by tandem reactions involving metathesis, the Prins reaction combined with Friedel-Crafts or Ritter reactions. Our expertise in asymmetric photochemistry has also allowed us to take advantage of photocycloadditions and sigmatropic isomerization processes to access original structures that are difficult to achieve by more conventional pathways.
forme_membres_ICBMS Fabienne FACHE

Fabienne FACHE

forme_membres_ICBMS Béatrice PELOTIER

Béatrice PELOTIER

forme_membres_ICBMS Olivier PIVA

Olivier PIVA

Professor and Head of ICBMS

Photochemistry is a unique tool for building complex or unusual structures. After focusing on the isomerization processes of photoinducted double bonds involving stereoselective protonations and the reactions of cycloadditions [2+2], we initiated a new project allowing access to propellanes, spiranic compounds and polyclic structures (homocubanes, twistanes,..) after photoredox or non-photoredox processes. Some of these reactions have been applied to the total synthesis of biologically active target molecules.
forme_membres_ICBMS Olivier PIVA

Olivier PIVA

Professor and Head of ICBMS

Our group is interested in radiochemistry and the use of positron emitters. Thus, we develop new radiochemical methods to label molecules with carbon-11 or fluorine-18. These labeled molecules are used in medical imaging (PETscan) to propose new pharmacological and diagnostic tools, in particular in the field of neuroscience.
forme_membres_ICBMS Thierry BILLARD

Thierry BILLARD

CNRS research director

Publications Find the most recent scientific contributions

Comprehensive Study and Development of a Metal-Free and Mild Nucleophilic Trifluoromethoxylation.

Clémence Bonnefoy, Armen Panossian, Gilles Hanquet, Frédéric R. Leroux, Fabien Toulgoat, Thierry Billard

Chem. Eur. J. 2023, 29, e202301513

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Organozinc reagents and nickel

O. Piva

Organozinc Derivatives and Transition Metal Catalysts: Formation of C-C Bonds by Cross-coupling, Ed. J. Cossy, De Gruyter 2023, pp. 63-116

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Perfluoroalkyl Selenoxides, Selenones and Selenoximines: General Preparation and Properties

A. de Zordo-Banliat, K. Grollier, N. Vanthuyne, S. Floquet, Th. Billard, G. Dagousset, B. Pégot, E. Magnier

Angew. Chem. Int. Ed. 2023, 62, e202300951

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Ketenimines as Intermediates To Access Difluoromethoxylated Scaffolds

A. Loison, G. Hanquet, F. Toulgoat, T. Billard, A. Panossian, F. R. Leroux

Org. Lett. 2022, 24, 8316-8321

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Access to hexahydroindeno[2,1-c]pyran based propellanes by a domino Prins/friedel-Crafts cyclization

Youssef Nassar, Fabienne Fache, Béatrice Pelotier, Olivier Piva

Synthesis, 2022, 54, 4622-4628.

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