SURCOOF
Synthesis, Use, Reactivity of Organic and Organofluorinated Compounds
The research in the SURCOOF group concerns two aspects:
(1)
The development of new strategies to synthesize compounds bearing new Emerging Fluorinated groups with specific properties, in particular for potential applications in medicinal chemistry. These methods are also applied in radiochemistry to obtain radiotracers labeled with fluorine-18 for medical imaging applications (in collaboration with CERMEP platform)
(2)
The synthesis of natural complexe molecules with unusual skeleta using photochemistry (conventionnal or photoredox processes), metathesis and other organometallic and organocatalyzed reactions performed in non standard media or activation (e.g. FBS, ionic liquids,…) with an emphasis for 3 component reactions and economy of steps and atoms.
Our team
Our group develops new reagents and new methods to introduce emerging fluorinated moieties onto organic compounds. In particular, the association of fluoroalkyl groups and chalcogenes has been developed and studied in the last years. Thus, new reagents allowing the introduction of CF3O, CF3S, CF3Se moities have been described. Moreover, the properties, such as the lipophilicity, of these various groups are measured.
Member of GIS-Fluor
Publications Find the most recent scientific contributions
Comprehensive Study and Development of a Metal-Free and Mild Nucleophilic Trifluoromethoxylation.
Clémence Bonnefoy, Armen Panossian, Gilles Hanquet, Frédéric R. Leroux, Fabien Toulgoat, Thierry Billard
Chem. Eur. J. 2023, 29, e202301513
Read the whole publicationOrganozinc reagents and nickel
O. Piva
Organozinc Derivatives and Transition Metal Catalysts: Formation of C-C Bonds by Cross-coupling, Ed. J. Cossy, De Gruyter 2023, pp. 63-116
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Perfluoroalkyl Selenoxides, Selenones and Selenoximines: General Preparation and Properties
A. de Zordo-Banliat, K. Grollier, N. Vanthuyne, S. Floquet, Th. Billard, G. Dagousset, B. Pégot, E. Magnier
Angew. Chem. Int. Ed. 2023, 62, e202300951
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Ketenimines as Intermediates To Access Difluoromethoxylated Scaffolds
A. Loison, G. Hanquet, F. Toulgoat, T. Billard, A. Panossian, F. R. Leroux
Org. Lett. 2022, 24, 8316-8321
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Access to hexahydroindeno[2,1-c]pyran based propellanes by a domino Prins/friedel-Crafts cyclization
Youssef Nassar, Fabienne Fache, Béatrice Pelotier, Olivier Piva