forme_membres_ICBMS Dr Thierry BILLARD

Dr Thierry BILLARD

CNRS research director


Thierry Billard obtained an engineer diploma from CPE Lyon and his master degree from University of Lyon. He carried out his Ph.D. on fluorine chemistry with B. Langlois (University of Lyon, France), a postdoctoral research in medicinal chemistry with L. Ghosez (University of Louvain-la-Neuve, Belgium) and has completed an industrial postdoctoral stay (Rhone-Poulenc, now Solvay). Afterwards, he joined CNRS in ICBMS (Lyon), where he was appointed research Director.

Member of the executive committee of the "French Fluorine Network"
Scientific administrator of the international Prize Henri Moissan

Research interests

His research activities are interdisciplinary involving chemistry and medicine with a focus on fluorine chemistry, medicinal chemistry, radiochemistry and their applications in medical imaging and neurosciences.

Member of GIS-Fluor 

Selected publications

Study of Carbamoyl Fluoride: Synthesis, Properties and Applications. C. Bonnefoy, E. Chefdeville, C. Tourvieille, A. Panossian, G. Hanquet, F. Leroux, F. Toulgoat, T. Billard, Chem. Eur. J. 2022, 28, e202201589.

Aromatic Trifluoromethylselenolation via Pd-catalyzed C−H functionalization. K. Grollier, E. Chefdeville, E. Jeanneau, T. Billard, Chem. Eur. J. 2021, 27, 12910-12916.

Study of a Stable “Trifluoromethoxide Anion Solution” Arising from 2,4-Dinitro-Trifluoromethoxybenzene. C. Bonnefoy, E. Chefdeville, A. Panossian, G. Hanquet, F. R. Leroux, F. Toulgoat, T. Billard, Chem. Eur. J. 2021, 27, 15986-15991.

Direct Electrophilic (Benzenesulfonyl)Difluoromethylthiolation with a Shelf-Stable Reagent. E. Ismalaj, D. Le Bars, T. Billard, Angew. Chem. Int. Ed. 2016, 55, 4790-4793.

Publications Find the most recent scientific contributions

Unlocking the Power of Acyl Fluorides: A Comprehensive Guide to Synthesis and Properties

Clémence Bonnefoy, Adrien Gallego, Clément Delobel, Betty Raynal, Maxime Decourt, Emmanuel Chefdeville, Gilles Hanquet, Armen Panossian, Frédéric R. Leroux, Fabien Toulgoat, Thierry Billard

Eur. J. Org. Chem. 2024, 27, e202400142

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SB-258585 reduces food motivation while blocking 5-HT6 receptors in the non-human primate striatum

M. Pitoy, L. Gauthier, J. Debatisse, J. Maulavé, E. Météreau, M. Beaudoin, K. Portier, V. Sgambato, T. Billard, L. Zimmer, S. Lancelot, L. Tremblay

Prog. Neuro-Psychopharmacol. Biol. Psychiatry 2024, 131, 110970

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Difluoromethoxylated Ketones as Building Blocks for the Synthesis of Challenging OCF2H-Bearing N-Heterocycles

A. Loison, G. Hanquet, F. Toulgoat, T. Billard, A. Panossian and F. R. Leroux

Eur. J. Org. Chem. 2023, 26, e202300695

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Comprehensive Study and Development of a Metal-Free and Mild Nucleophilic Trifluoromethoxylation.

Clémence Bonnefoy, Armen Panossian, Gilles Hanquet, Frédéric R. Leroux, Fabien Toulgoat, Thierry Billard

Chem. Eur. J. 2023, 29, e202301513

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Perfluoroalkyl Selenoxides, Selenones and Selenoximines: General Preparation and Properties

A. de Zordo-Banliat, K. Grollier, N. Vanthuyne, S. Floquet, Th. Billard, G. Dagousset, B. Pégot, E. Magnier

Angew. Chem. Int. Ed. 2023, 62, e202300951

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