Dr Sylvie RADIX

About Sylvie

After a PhD in synthesis methodology dedicated to the development of trifluoromethylation reactions from fluoroform, Sylvie Radix worked as a post-doctoral researcher in the field of organometallic chemistry in England (Prof. Ron Grigg, MIDAS Lab, University of Leeds) and in Switzerland (Prof. Peter E. Kündig, University of Geneva) and then in the field of total synthesis at the Faculty of Pharmacy of Lyon (Prof. Roland Barret, EA3741) in collaboration with the Pierre Fabre Laboratories. After working as a full-time temporary teaching researcher assistant, Sylvie Radix was recruited as a lecturer in organic chemistry at the Faculty of Pharmacy of Lyon in 2004. She obtained the accreditation to supervise research (HDR diploma) in medicinal chemistry in 2009.

Research interests

 Sylvie Radix is involved in projects focused on infectiology research field. She has been working for several years to design and synthesize antibiotic-resistance reversal agents (efflux pump inhibitors, metallo-b-lactamase inhibitors), antibacterial and antiviral compounds. This research work led her to develop syntheses in heterocyclic chemistry, in steroid chemistry or in organometallic chemistry. 

Selected publications

- Pharmacomodulation of a ligand targeting the HBV capsid hydrophobic pocket.

Briday, M.; Hallé, F.; Lecoq, L.; Radix, S.; Martin, J.; Montserret, R.; Dujardin, M.; Fogeron, M-L.; Nassal, M.; Meier, B. H.; Lomberget T.; Böckmann, A. Chem. Sci. 2022, 13, 8840–8847.

- A journey through Hemetsberger-Knittel, Leimgruber-Batcho and Bartoli reactions: access to several hydroxy 5- and 6-azaindoles.

Radix, S.; Hallé, F.; Mahiout, Z.; Teissonnière, A.; Bouchez, G.; Auberger, L.; Barret, R.; Lomberget, T. Helv. Chim. Acta 2022, 105, e202100211.

- Synthesis and biological evaluation of zinc chelating compounds as metallo-β-lactamase inhibitors.

Kildahl-Andersen, G; Schnaars, C; Prandina, A; Radix, S; Le Borgne, M; Jordheim, L.P.; Gjøen, T; Santos Andresen, A.M.; Lauksund, S; Fröhlich, C; Samuelsen, Ø; Rongved, P; Åstrand, O.A.H. Med. Chem. Commun. 2019, 10, 528-537.

- Synthesis and biological evaluation of new dipicolylamine zinc chelators as metallo-β-lactamase inhibitors.

Prandina, A.; Radix, S.; Le Borgne, M.; Jordheim, L.P.; Bousfiha, Z; Fröhlich, C.; Schröder Leiros, H.-K.; Samuelsen, Ø; Frøvold, E.; Rongved, P.; Åstrand, O.A.H. Tetrahedron 2019, 75, 1525-1540.