forme_membres_ICBMS M Gilles RAUTUREAU



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Gilles Rautureau earned a PhD in structural biology after completing a master's degree in biochemistry. At the Center de Biophysics Moléculaire d'Orléans, he studied several PEBP proteins involved in cancer and their structure-function relationships by NMR.  After that, he worked as a postdoctoral fellow at the Walter and Eliza Hall Institute in Melbourne and determined by NMR and crystallography the structure and interactions of Bcl-2 family proteins involved in apoptosis. His next step was to work at the University College Dublin on hepatitis B virus proteins, and in particular its polymerase, a difficult-to-produce protein that is still a major target for therapeutic development. Gilles Rautureau joined the Ecole Normale Supérieure de Lyon in 2012 as a lecturer where he developed with Bénédicte Elena-Herrmann NMR metabolomics methods for biological and medical studies. He was appointed Professor at the University Claude Bernard Lyon 1 and the ICBMS in 2022.

Research interests

Gilles Rautureau uses NMR metabolomic approaches to address a wide range of scientific questions:
- to conduct biomedical studies on human or animal models for diagnostic or discriminatory purposes
- to determine how biological and environmental perturbations affect metabolic processes
- to investigate the role and impact of metabolic enzymes in cellular metabolism
he has done research in a wide variety of areas, with several collaborators and assessed a variety of samples types (bacteria, cell cultures, organs, and animal models biofluids), 
During the past decade, he has been collaborating closely with the CarMen laboratory at the Hospital de Lyon Sud to study metabolic syndrome as well as overnutrition-related diseases.

Selected publications

Dietary obesity in mice is associated with lipid deposition and metabolic shifts in the lungs sharing features with the liver. Rautureau GJP, Morio B, Guibert S, Lefevre, Perrier J, Alves A, Chauvin MA, Pinteur C, Monet MA, Godet M, Madec AM, Rieusset J, Mey A, Panthu B.

Scientific Reports (2021) 11:8712 doi: 10.1038/s41598-021-88097-8


Cell-Free Protein Synthesis Enhancement from Real-Time NMR Metabolite Kinetics: Redirecting Energy Fluxes in Hybrid RRL Systems. Panthu B, Ohlmann T, Perrier J, Schlattner U, Jalinot P, Elena-Herrmann B, Rautureau GJP.

ACS Synthetic Biology. 2017 Oct 2. doi: 10.1021/acssynbio.7b00280


Metabolic phenotyping of adipose derived stem cells reveals a unique signature and intrinsic differences between fat pads. Lefevre C, Panthu B, Naville D, Guibert S, Pinteur C, Elena-Herrmann B, Vidal H, Rautureau GJP, Mey A.

Stem Cells International, vol. 2019. doi: 10.1155/2019/9323864.


Identification of Bacterial Species by Untargeted NMR Spectroscopy of the Exo-metabolomePalama TL, Canard I, Rautureau GJP, Mirande C, Chatellier S, Elena-Herrmann B.

Analyst, 2016 Aug 7;141(15):4558-61. doi: 10.1039/c6an00393a



Publications Find the most recent scientific contributions

How Warburg-Associated Lactic Acidosis Rewires Cancer Cell Energy Metabolism to Resist Glucose Deprivation

Daverio, Z., Balcerczyk, A., Rautureau, G.J.P., Panthu, B.

Cancers 2023, 15, 1417.

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Dietary obesity in mice is associated with lipid deposition and metabolic shifts in the lungs sharing features with the liver

Rautureau, G.J.P., Morio, B., Guibert, S. et al.

Sci Rep (2021) 11, 8712

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A hexokinase isoenzyme switch in human liver cancer cells promotes lipogenesis and enhances innate immunity

Perrin-Cocon, L., Vidalain, PO., Jacquemin, C. et al.

Commun Biol (2021) 4, 217

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Use of Nanovesicles from Orange Juice to Reverse Diet-Induced Gut Modifications in Diet-Induced Obese Mice

Berger E, Colosetti P, Jalabert A, Meugnier E, Wiklander OPB, Jouhet J, Errazurig-Cerda E, Chanon S, Gupta D, Rautureau GJP, Geloen A, El-Andaloussi S, Panthu B, Rieusset J, Rome S.

Mol Ther Methods Clin Dev. (2020) 18:880-892

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