forme_membres_ICBMS Mme Leyre BRIZUELA-MADRID


Associate professor

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Leyre Brizuela Madrid has realised a license in Biologie and a Master degree in Biochemistry and Molecular Biology in Basque country university (Lejona, Spain) from 1996 until 2001. She has obtained her PhD in september 2006 in the “Hormonal regulation” lab directed by Pr Antonio Gomez Munoz, at Science and Technology faculty from Basque country university. Afterwards, she joined “Sphingolipid&cancer” laboratory directed by Dr Olivier Cuvillier at the Pharmacology and Structural biology institute (IPBS CNRS UMR 5089) at Toulouse as a junior postdoc. She was recruited as an assistant professor in CNU 64 section (Biochemistry and Molecular Biology) en September of 2013 at Claude Bernard Lyon 1 university. She recently obtained her HDR (habilitation à diriger la recherche) en june 2022. She has been recently promoted to associate professor.

Research interests

Leyre Brizuela Madrid is interested in the role of sphingolipid and phospholipid metabolism in different pathologies concerned by a pathological mineralization, as prostate cancer-derived bone metastasis, chronic kidney disease-derived vascular calcification and spondylarthrites. Leyre Brizuela Madrid research projects have a translational approach with in vitro, in cellulo, in vivo models and patients’ samples analyses.

Selected publications

Borel M, Cuvillier O, Magne D, Mebarek S, Brizuela L. Increased phospholipase D activity contributes to tumorigenesis in prostate cancer cell models. Mol Cell Biochem. 2020 Oct;473(1-2):263-279. doi: 10.1007/s11010-020-03827-2. Epub 2020 Jul 14. PMID: 32661773.


Badran B, Hussein N, Buchet R, Brizuela L, Mebarek S. Phospholipase D: A new mediator during high phosphate-induced vascular calcification associated with chronic kidney disease. J Cell Physiol. 2019 Apr;234(4):4825-4839. doi: 10.1002/jcp.27281. Epub 2018 Sep 12. PMID: 30207376.


Bougault C, El Jamal A, Briolay A, Mebarek S, Boutet MA, Garraud T, Le Goff B, Blanchard F, Magne D, Brizuela L. Involvement of sphingosine kinase/sphingosine 1-phosphate metabolic pathway in spondyloarthritis. Bone. 2017 Oct;103:150-158. doi: 10.1016/j.bone.2017.07.002. Epub 2017 Jul 3. PMID: 28684192.

Publications Find the most recent scientific contributions

Do Media Extracellular Vesicles and Extracellular Vesicles Bound to the Extracellular Matrix Represent Distinct Types of Vesicles?

Mebarek S, Buchet R, Pikula S, Strzelecka-Kiliszek A, Brizuela L, Corti G, Collacchi F, Anghieri G, Magrini A, Ciancaglini P, Millan JL, Davies O, Bottini M

Biomolecules . 2023 Dec 28;14(1):42

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Targeting Sphingosine 1-Phosphate Metabolism as a Therapeutic Avenue for Prostate Cancer

Mebarek S, Skafi N, Brizuela-Madrid L

Cancers (Basel) . 2023 May 12;15(10):2732

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Deciphering the recombinant thermostable phosphatidylcholine-specific phospholipase C activity from Bacillus thuringiensis: Biochemical and interfacial properties

Eddehech, A; Smichi, N; Violot, S.; Bettler, E.; Brizuela, L.; Noiriel, A.; Abousalham, A.; Zarai, Z.

Int. J. Mol. Biol. Macromol. 2021, 166, 1131-1141

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Phospholipase D inhibitors screening: Probing and evaluation of ancient and novel molecules

Arhab, Y; Bessaa, K; Abla, H.; Aydin, M.; Comte, A.; Brizuela, L.; Mebarek, S.; Perret, F.; Cherrier, M.; Abousalham, A.; Noiriel, A.

Colloids Surf. A Physicochem. Eng. Asp. 2021, 630, 127629

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Prostate cancer-derived exosomes promote osteoblast differentiation and activity through phospholipase D2

Borel M, Lollo G, Magne D, Buchet R, Brizuela L, Mebarek S.

Biochim Biophys Acta Mol Basis Dis. (2020) 1866(12):165919

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