forme_membres_ICBMS Dr Nuno Monteiro

Dr Nuno Monteiro

CNRS Research associate

About Nuno

Nuno studied chemistry at the University of Lyon where he completed his PhD in 1992 working on the development of transition metal (Pd, Cu)-catalyzed Conia-ene-type cyclizations under the guidance of Jacques Goré and Geneviève Balme. Following a one-year period as a contractual lecturer, he joined the group of Varinder K. Aggarwal (University of Sheffield, England) as a Marie Curie post-doctoral fellow to work on the synthesis of carbocyclic analogues of peptidyl nucleoside antibiotics (Polyoxins, nikkomycins) exploiting new Pd-catalyzed carbon-heteroatom bond forming strategies. In 1996 he returned to Lyon where he was appointed as a CNRS researcher.

Research interests

Nuno’s early research interests have concerned the development of transition metal-catalyzed methods toward the construction and functionalization of carbo- and heterocyclic compounds, including cross-coupling, cascade and multicomponent, as well as diversity-oriented strategies (Pd, Cu). Recently, he became interested in organofluorine chemistry, and developed new transition metal catalyzed, radical fluoroalkylation and fluoroacylation methods (Pd, Cu, Ru) to access fluorinated ketones and fluorinated heterocycles. Today, as a member of the SCORE team, he is involved in the development of new cross-coupling strategies requiring metal-mediated strong bond activation of new electrophiles (amides, esters, ethers), notably via metallaphotoredox approaches (Ni).

Selected publications

Silyl radical-mediated cross-electrophile coupling of N-(acyl)-imides with alkyl bromides under photoredox/nickel dual catalysis. Kerackian, T.; Reina, A.; Bouyssi, D.; Monteiro, N.; Amgoune, A. Org. Lett. 2020, 22, 2240.

Nickel-catalyzed mono-selective a-arylation of acetone with aryl chlorides and phenol derivatives. Derhamine, S. A.; Krachko, T.; Monteiro, N.; Schranck, J.; Tlili, A.; Amgoune, A. Angew. Chem. Int. Ed. 2020, 59, 18948.

Development and Mechanistic Investigations of a Base-Free Suzuki-Miyaura Cross-Coupling of a,a,a-Difluoroacetamides via C–N Bond Cleavage. Reina, A. ; Krachko, T. ; Onida, K. ; Bouyssi, D. ; Jeanneau, E. ; Monteiro, N. ; Amgoune, A. ACS Catal. 2020, 10, 2189.

Copper-Catalyzed Double C-H Alkylation of Aldehyde-Derived N,N-Dialkylhydrazones with Polyhalomethanes: Flexible Access to 4-Functionalized Pyrazoles. Prieto, A.; Bouyssi, D.; Monteiro, N. ACS Catal. 2016, 6, 7197.

Palladium-Catalyzed C(sp2)-H Alkylation of Aldehyde-Derived Hydrazones with Functionalized Difluoromethyl Bromides. Prieto, A.; Melot, R.; Bouyssi, D.; Monteiro, N. Angew. Chem. Int. Ed. 2016, 55, 1885.


Publications Find the most recent scientific contributions

Nickel-Catalyzed Electro-Reductive Cross-Coupling of Aliphatic N-Acyl Imides with Alkyl Halides as a Strategy for Dialkyl Ketone Synthesis: Scope and Mechanistic Investigations

Kerackian, Taline; Bouyssi, Didier; Pilet, Guillaume; Médebielle, Maurice; Monteiro, Nuno: Vantourout, Julien; and Amgoune, Abderrahmane

ACS Catalysis, 2022, 12, 12315-12325

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C(sp3)–H Bond Acylation with N-Acyl Imides under Photoredox/ Nickel Dual Catalysis

Kerackian, Taline; Reina, Antonio, Krachko, Tetania; Bouyssi, Didier; Monteiro, Nuno; Amgoune, Abderrahmane

Synlett 2021, 32, 1531-1536

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Nickel-Catalyzed Mono-Selective α-Arylation of Acetone with Aryl Chlorides and Phenol Derivatives

Sary Abou Derhamine, Tetiana Krachko, Nuno Monteiro, Guillaume Pilet, Johannes Schranck, Anis Tlili,* Abderrahmane Amgoune*

Angew. Chem. Int. Ed. 2020, 59, 18948-18953

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Silyl Radical Mediated Cross-Electrophile Coupling of N-Acyl-imides with Alkyl Bromides Under Photoredox/Nickel Dual Catalysis

Kerackian, Taline; Reina, Antonio; Bouyssi, Didier; Monteiro, Nuno; Amgoune, Abderrahmane

Org. Lett. 2020, 22, 6, 2240-2245

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Development and Mechanistic Investigations of a Base-Free Suzuki–Miyaura Cross-Coupling of α,α-Difluoroacetamides via C–N Bond Cleavage

Reina, Antonio, Krachko, Tetania; Onida, Killian; Bouyssi, Didier; Monteiro, Nuno; Amgoune, Abderrahmane

ACS Catal. 2020, 10, 3, 2189–2197

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