Mme Saïda MEBAREK

Bio

Saida Mebarek has obtained her PhD degree from INSA Lyon in january 2006 in the laboratory of lipids and membrane physiopathology, INSA-INSERM UMR585. Between september 2006 to september 2007, she realised one year post-doctoral internship at Institute of Developmental Biology of Marseilles (UMR CNRS 6126). In september 2007, she joined the University Claude Bernard Lyon 1 as associate professor and obtained an accreditation to supervise research in september 2015.

Research interests

Saida Mebarek is interested in the vascular disturbances involved in the metabolic syndrome, in particular those in chronic renal failure and in atherosclerosis. Her research focuses on the role of lipid signaling, in particular the involvement of phospholipase D in physiological but also pathological mineralization processes, such as vascular calcification and bone metastasis in prostate cancer. She is in charge of the aspects of extracellular vesicles projects.She is also interested in the function of extracellular vesicles (exosomes and matrix vesicles) which represent an alternative and versatile mode of communication, and open the door to new concepts and opportunities from a therapeutic and biological point of view. Her work deals with the mechanisms involved in the initiation of mineralization in the so-called matrix vesicles that are released by hypertrophic chondrocytes, osteoblasts and odontoblasts that are relevant to understanding pathophysiological conditions such as atherosclerosis, chronic kidney disease and diabetes.

Publications

Inhibition of alkaline phosphatase impairs dyslipidemia and protects mice from atherosclerosis.

Bessueille L, Kawtharany L, Quillard T, Goettsch C, Briolay A, Taraconat N, Balayssac S, Gilard V, Mebarek S, Peyruchaud O, Duboeuf F, Bouillot C, Pinkerton A, Mechtouff L, Buchet R, Hamade E, Zibara K, Fonta C, Canet-Soulas E, Millan JL, Magne D. Transl Res. 2022 Jun 17:S1931-5244(22)00144-X. doi: 10.1016/j.trsl.2022.06.010.

Hydrolysis of Extracellular ATP by Vascular Smooth Muscle Cells Transdifferentiated into Chondrocytes Generates Pi but Not PPi.

Buchet R, Tribes C, Rouaix V, Doumèche B, Fiore M, Wu Y, Magne D, Mebarek S. Int J Mol Sci. 2021 Mar 14;22(6):2948. doi: 10.3390/ijms22062948.

Prostate cancer-derived exosomes promote osteoblast differentiation and activity through phospholipase D2.

Borel M, Lollo G, Magne D, Buchet R, Brizuela L, Mebarek S. Biochim Biophys Acta Mol Basis Dis. 2020 Dec 1;1866(12):165919. doi: 10.1016/j.bbadis.2020.165919.

Phospholipase D: A new mediator during high phosphate-induced vascular calcification associated with chronic kidney disease.

Skafi N, Abdallah D, Soulage C, Reibel S, Vitale N, Hamade E, Faour W, Magne D, Badran B, Hussein N, Buchet R, Brizuela L, Mebarek S. J Cell Physiol. 2019 Apr;234(4):4825-4839. doi: 10.1002/jcp.27281.