Organic Synthetic MethodSynthesis and Methodology applied to biomolecules
Total synthesis of a target molecule with most often interesting or even unique biological properties represents a challenge to demonstrate the applicability of a pre-established methodologies or in contrast the need to develop new processes. In the two cases, it is a unique opportunity for learning and mastering organic chemistry. The research carried out in the unit is focused on many targets (alkaloids, terpenes, heterocycles, polyketides ...) involving organometallic couplings, organo- and biocatalyzed reactions, multicomponent reactions, electro- and photochemical processes but also the valorization of natural products as highly functionnalized scaffolds.
Publications Find the most recent scientific contributions
How can we solve the problem of bioprintability to overcome the bioprinting challenges?
Alizée Mosnier, Imen Halima & Edwin-Joffrey Courtial
MRS Bulletin (2024)
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Unlocking the potential of bio-inspired bioinks: A collective breakthrough in mammalian tissue bioprinting
Marquette, C. A.; Chastagnier, L.; Da Sousa, B.; Chocarro-Wrona, C.; Courtial, E.-J.; Rae, E.; Thomann, C.; Carre, A.; Essayan, L.; Pasuch, A. J.; Mosnier, A.; Devillard, C.; Petiot, E.; Lemarié, L.; Matera, E.-L.; Simoes, M.; Dumontet, C.; Cuella Martin, C.; Pechtimaldjian, L.; Pécheur, E.-I.; Maguer-Satta, V.; Michelet, M.; Plissonnier, M.-L.; Archer, F.; Moreau, K.; Dufaud, M.; Zaupa, C.; Balloul, J.-M.; Pruvost, Q.; Dauphin, T.; Mosser, M.; Pragnère, S.,
Bioprinting, 2024, 41: e00351
Read the whole publicationSpace radiation damage rescued by inhibition of key spaceflight associated miRNAs
J. Tyson McDonald, Jang Keun Kim,Lily Farmerie,Meghan L. Johnson, Nidia S. Trovao, Shehbeel Arif, Keith Siew, Sergey Tsoy, Yaron Bram, Jiwoon Park,EliahOverbey,Krista Ryon, Jeffrey Haltom, Urminder Singh, Francisco J. Enguita, Victoria Zaksas, Joseph W. Guarnieri, Michael Topper, Douglas C. Wallace, Cem Meydan, Stephen Baylin, Robert Meller, Masafumi Muratani, D.Marshall Porterfield, Brett Kaufman, Marcelo A. Mori, Stephen B. Walsh, Dominique Sigaudo-Roussel, Saida Mebarek, Massimo Bottini, Christophe A. Marquette, Eve Syrkin Wurtele, Robert E. Schwartz, DiegoGaleano, Christopher E. Mason, Peter Grabham & Afshin Beheshti
Nat. Commun. 2024, 15: 4825
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Convergent synthesis of N-(4-(3-ethoxy-2-hydroxypropyl)phenyl)-2-(methylthio) acetamide precursor of the suplatast tosylate
Margherita Colombo, Yousef Joqmara, Guillaume Pilet, Michele Fiore
Trends in Organic Chemistry, 2024, 24, 79-92
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