Total synthesis of a target molecule with most often interesting or even unique biological properties represents a challenge to demonstrate the applicability of a pre-established methodologies or in contrast the need to develop new processes. In the two cases, it is a unique opportunity for learning and mastering organic chemistry. The research carried out in the unit is focused on many targets (alkaloids, terpenes, heterocycles, polyketides ...) involving organometallic couplings, organo- and biocatalyzed reactions, multicomponent reactions, electro- and photochemical processes but also the valorization of natural products as highly functionnalized scaffolds.