Organic Synthetic MethodSynthesis and Methodology applied to biomolecules
Total synthesis of a target molecule with most often interesting or even unique biological properties represents a challenge to demonstrate the applicability of a pre-established methodologies or in contrast the need to develop new processes. In the two cases, it is a unique opportunity for learning and mastering organic chemistry. The research carried out in the unit is focused on many targets (alkaloids, terpenes, heterocycles, polyketides ...) involving organometallic couplings, organo- and biocatalyzed reactions, multicomponent reactions, electro- and photochemical processes but also the valorization of natural products as highly functionnalized scaffolds.
Publications Find the most recent scientific contributions
Electroreductive Synthesis of Nickel(0) complexes
Rubel, Camille Z.; Cao, Yilin; Ewing, Tamara El-Hayek; Laudadio, Gabriele; Beutner, Gregory L.; Wisniewski, Steven R.; Wu, Xiangyu; Baran, Phil S.; Vantourout, Julien C.; Engle, Keary M.
Angew. Chem. Int. Ed. 2023, e202311557
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Paper-based electrodes as a tool for detecting ligninolytic enzymatic activities
Fall, I., Doumèche, B., Abdellaoui, S., Rémond C., Rakotoarivonina, H., Ochs M.
Bioelectrochem. 2023, 156, 108609
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Synthetic outer membrane vesicles bearing Tn antigen
Carolina Chieffo, Arnaud Comte, Peter Strazewski and Michele Fiore*
European Journal of Organic Chemistry 2023
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Difluoromethoxylated Ketones as Building Blocks for the Synthesis of Challenging OCF2H-Bearing N-Heterocycles
A. Loison, G. Hanquet, F. Toulgoat, T. Billard, A. Panossian and F. R. Leroux
Eur. J. Org. Chem. 2023, 26, e202300695
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Electrochemically Driven Nickel-Catalyzed Halogenation of Unsaturated Halide and Triflate Derivatives
Chen, Ming-Yu; Charvet, S.; Payard, Pierre-Adrien; Perrin, Marie-Eve L.; Vantourout, Julien C.