Organic Synthetic MethodSynthesis and Methodology applied to biomolecules

Total synthesis of a target molecule with most often interesting or even unique biological properties represents a challenge to demonstrate the applicability of a pre-established methodologies or in contrast the need to develop new processes. In the two cases, it is a unique opportunity for learning and mastering organic chemistry. The research carried out in the unit is focused on many targets (alkaloids, terpenes, heterocycles, polyketides ...) involving organometallic couplings, organo- and biocatalyzed reactions, multicomponent reactions, electro- and photochemical processes but also the valorization of natural products as highly functionnalized scaffolds.

Publications Find the most recent scientific contributions

Biochemical, Bioinformatic, and Structural Comparisons of Transketolases and Position of Human Transketolase in the Enzyme Evolution

Biochemistry, 2024

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Confined bioprinting and culture in inflatable bioreactor for the sterile bioproduction of tissues and organs

Scientific Reports 2024, 14: 11003

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The Use of 5-Hydroxymethylfurfural (5-HMF) in Multi- Component Hantzsch Dihydropyridine Synthesis

Jingjing Jiang, Yves Queneau, Florence Popowycz

ChemSusChem 2024, e202301782

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3D MODEL of an anatomically inert human hand: feasibility study

Lucchino, N.; Pialat, J-B.; Marquette, C.; Courtial, E.; Erhard, L.; Voulliaume, D.; Mojallal, A.; Gazarian, A.

Hand Surgery and Rehabilitation 101709

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Hydride-free reduction of propargyl electrophiles: A nickel-catalyzed photoredox strategy for allene synthesis

Hu, Tingjun; Fagué, Vincent; Bouyssi, Didier; Monteiro, Nuno; Amgoune, Abderrahmane

Green Chem, 2024, Accepted Manuscript

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